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Schistosoma mansoni encodes SMT3B and SMT3C molecules responsible for post-translational modification of cellular proteins
(ELSEVIER IRELAND LTD, 2008)
The sumoylation pathway is a post-translational modification of nuclear proteins widespread among several organisms. SMT3C is the main protein involved in this process and it is covalently conjugated to a diverse assortment ...
Coxsackievirus 135 induced apoptosis of HeLa cells: Effects on p53 and SUMO
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2010)
Coxsackievirus B5 (CVB5), a human enterovirus of the family Picornaviridae, is a frequent cause of acute and chronic human diseases. The pathogenesis of enteroviral infections is not completely understood, and the fate of ...
Akt/PKB: one kinase, many modifications
(Portland Press, 2015-06)
Akt/PKB, a serine/threonine kinase member of the AGC family of proteins, is involved in the regulation of a plethora of cellular processes triggered by a wide diversity of extracellular signals and is thus considered a key ...
RSUME is implicated in tumorigenesis and metastasis of pancreatic neuroendocrine tumors
(Impact Journals LLC, 2016-09)
The factors triggering pancreatic neuroendocrine tumor (PanNET) progression are largely unknown. Here we investigated the role and mechanisms of the sumoylation enhancing protein RSUME in PanNET tumorigenesis. Immunohistochemical ...
The estrogen receptor alpha nuclear localization sequence is critical for fulvestrant-induced degradation of the receptor
(Elsevier Ireland, 2015-11)
Fulvestrant, a selective estrogen receptor down-regulator (SERD) is a pure competitive antagonist of estrogen receptor alpha (ERα). Fulvestrant binds ERα and reduces the receptor's half-life by increasing protein turnover, ...
A Draft of the Human Septin Interactome
(PUBLIC LIBRARY SCIENCE, 2010)
Background: Septins belong to the GTPase superclass of proteins and have been functionally implicated in cytokinesis and the maintenance of cellular morphology. They are found in all eukaryotes, except in plants. In mammals, ...