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Influence of gasoline inhalation on the enantioselective pharmacokinetics of fluoxetine in rats
(2013-03-01)
Fluoxetine is used clinically as a racemic mixture of (+)-(S) and (-)-(R) enantiomers for the treatment of depression. CYP2D6 catalyzes the metabolism of both fluoxetine enantiomers. We aimed to evaluate whether exposure ...
Conformational Polymorphism in Racemic Crystals of the Diuretic Drug Chlortalidone
(AMER CHEMICAL SOC, 2009)
Chlortalidone (HIGROTON) is a diuretic drug widely used in antihypertensive therapy. Thus far, only two solid-state polymorphs of chlortalidone have been reported. We elucidated the structure of chlortalidone form I and a ...
Absolute Configuration and Selective Trypanocidal Activity of Gaudichaudianic Acid Enantiomers
(AMER CHEMICAL SOC, 2011)
Gaudichaudianic acid, a prenylated chromene isolated from Piper gaudichaudianum, has been described as a potent trypanocidal compound against the Y-strain of Trypanosoma cruzi. We herein describe its isolation as a racemic ...
Enantioselective esterification of racemic ibuprofen with ethanol as reactant and solvent catalyzed by immobilized lipase: experimental and molecular modeling aspects
(John Wiley & Sons Ltd, 2009-05-13)
In the last years enantioselective esterification of racemic ibuprofen performed in organic solvent media and catalyzed by lipases has been proposed as an effective way to increase the concentration of unesterified S-ibuprofen ...
Resolution and Absolute Configuration Assignment of a Natural Racemic Chromane from Peperomia obtusifolia (Piperaceae)
(WILEY-LISS, 2009)
The resolution of the natural racemic chromane 3,4-dihydro-5-hydroxy-2,7-dimethyl-8-(3 ``-methyl-2 ``-butenyl)-2-(4`-methyl-1`,3`-pentadienyl)-2H-1-benzopyran-6-carboxylic acid (1) isolated from the leaves of Peperomia ...
Haemodynamic effects of intoxication with bupivacaine and enantiomeric excess mixture. experimental study in swine
(Assoc Medica BrasileiraSao PauloBrasil, 2007)
Atenolol characterization in solid formulations available in Brazilian market
(2013)
Atenolol is the most used drug in Brazil to hypertension treatment. Two crystal structures are known for this molecule: a racemic form (R,S)-atenolol and a pure form S-atenolol. The racemic form is found in commercial ...