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In vitro characterization of coevaporates containing chitosan for colonic drug delivery
(Elsevier B.V., 2009-10-15)
A relative simple drug delivery system in the form of coevaporates were prepared and analyzed. They were based on chitosan (CS), a polysaccharide that undergoes specific degradation by colonic enzymes. Enteric polymers, ...
Blends of cross-linked high amylose starch/pectin loaded with diclofenac
(2013-01-02)
Polymers blends represent an important approach to obtain materials with modulated properties to reach different and desired properties in designing drug delivery systems in order to fulfill therapeutic needs. The aim of ...
Polyacrylic acid polymers hydrogels intended to topical drug delivery: preparation and characterization
(Informa Healthcare, 2015-06-01)
Context: Bioadhesiviness of polyacrylic acid polymers make them promising hydrogels to design topical drug delivery systems, allowing a close contact with biological substrate as well as an enhanced local concentration ...
Mucoadhesive drug delivery systems
(Universidade de São Paulo (USP), Conjunto Quimicas, 2010-01-01)
Drug actions can be improved by developing new drug delivery systems, such as the mucoadhesive system. These systems remain in close contact with the absorption tissue, the mucous membrane, releasing, the drug at the action ...
Chitosan-pectin multiparticulate systems associated with enteric polymers for colonic drug delivery
(Elsevier B.V., 2010-10-15)
The great challenge in using native degradable polysaccharides for the development of drug delivery systems is their high aqueous solubility, which may contribute to the undesirable premature and localized release of the ...
Estratégias biotecnológicas para a liberação controlada de antígenos e adjuvantes em vacinas através de lipossomas
(2006-10-01)
Liposomes (LP) are colloidal systems with ability to compartmentalize therapeutic molecules in order to improve biological activity, decreases the potential toxicity, and to obtain prolonged effect. In this work it was ...
Novel Polymeric Nanoparticles Intended for Ophthalmic Administration of Acetazolamide
(Elsevier, 2016-10)
Glaucoma is characterized by increased intraocular pressure (IOP) that results in blindness if it remains untreated. Acetazolamide (AZM) is a carbonic anhydrase inhibitor, mainly used to reduce IOP in the treatment of ...
Encapsulação da rifampicina em matrizes poliméricas flutuantes obtidas por liofilização a partir de metilcelulose e ftalato de hidroxipropilmetilcelulose. Avaliação da liberação in vitro
(2001-12-01)
Floating multiparticles for oral administration with different compositions were studied from a matricial polymeric system to obtain sustained release. The polymers used in the multiparticles constitution were methylceullose ...
PLA nano- and microparticles for drug delivery: An overview of the methods of preparation
(Wiley VCH Verlag, 2007-06)
The controlled release of medicaments remains the most convenient way of drug delivery. Therefore, a wide variety of reports can be found in the open literature dealing with drug delivery systems. In particular, the use ...