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Slit/robo signaling regulates multiple stages of the development of the drosophila motion detection system
(Frontiers Media, 2021)
Neurogenesis is achieved through a sequence of steps that include specification and differentiation of progenitors into mature neurons. Frequently, precursors migrate to distinct positions before terminal differentiation. ...
Phosphoproteome profiling reveals critical role of JAK-STAT signaling in maintaining chemoresistance in breast cancer
(2017-01-01)
Breast cancer is responsible for 25% of cancer cases and 15% of cancer death among women. Treatment is usually prolonged and hampered by the development of chemoresistance. The molecular mechanisms maintaining the ...
Prediction of Oncogenic Interactions and Cancer-Related Signaling Networks Based on Network Topology
(Public Library Science, 2013-10-25)
Cancer has been increasingly recognized as a systems biology disease since many investigators have demonstrated that this malignant phenotype emerges from abnormal protein-protein, regulatory and metabolic interactions ...
A catalytically-inactive snake venom Lys49 phospholipase A2 homolog induces expression of cyclooxygenase-2 and production of prostaglandins through selected signaling pathways in macrophages
(2013-05-15)
The effects of a snakevenom Lys-49phospholipaseA2 (PLA2) homolog named MT-II,devoid of enzymatic activity, on the biosynthesis of prostaglandins and protein expression of cyclooxygenase-2(COX-2) and signaling pathways ...
Cytochrome c, a hub linking energy, redox, stress and signalling pathways in mitochondria and other cell compartments
(Wiley Blackwell Publishing, Inc, 2016-04)
Cytochrome c (CYTc) is a soluble redox-active heme protein that transfers electrons from Complex III to Complex IV in the cyanide-sensitive mitochondrial respiratory pathway. CYTc biogenesis is a complex process that ...
Protein Blend and Casein Supplementations before Inactive Phase Similarly Activate Mechanistic Target of Rapamycin Signaling in Rat Skeletal Muscle
(Wolters Kluwer Medknow Publications, 2020-07-01)
During overnight sleep, the longest postabsorptive and inactive phase of the day causes protein catabolism and loss. However, the daytime ingestion of dairy proteins has been shown to stimulate muscle protein synthesis and ...
RANKL expression is differentially modulated by TLR2 and TLR4 signaling in fibroblasts and osteoblasts
(2014)
Resident, non-immune cells express various pattern-recognition receptors and produce inflammatory cytokines in response to microbial antigens, during the innate immune response. Alveolar bone resorption is the hallmark of ...