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Lack of signaling by IL-4 or by IL-4/IL-13 has more attenuating effects on Leishmania amazonensis dorsal skin - than on footpad-infected mice
(ACADEMIC PRESS INC ELSEVIER SCIENCESAN DIEGO, 2012)
Lesion development in tegumentary leishmaniasis is markedly influenced by the inoculation site and the type and number of injected infective forms. This and the yet unclear contribution of Th2 cytokines as susceptibility ...
Interleukin 4 induces the expression of inducible nitric oxide synthase in eosinophils
(Elsevier B.V., 2005-05-07)
We investigated the effects of the Th-2-like cytokines IL-4 and IL-13 and of IL-10 on the induction of iNOS and NO production in rat eosinophils. Addition of mIL-4 to the eosinophil culture increased iNOS activity and ...
Stimulation of IL-6 Cytokines in Fibroblasts by Toll-like Receptors 2
(Sage Publications Inc, 2010-08-01)
The osteotropic interleukin-6 (IL-6) types of cytokines IL-6, IL-11, and leukemia inhibitory factor (LIF), but not oncostatin M, are expressed by human gingival fibroblasts, and their expressions are regulated by IL-1 and ...
Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFN gamma production
(NATL ACAD SCIENCES, 2009)
IL-23/IL-17-induced neutrophil recruitment plays a pivotal role in rheumatoid arthritis (RA). However, the mechanism of the neutrophil recruitment is obscure. Here we report that prostaglandin enhances the IL-23/IL-17-induced ...
Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism
(ELSEVIER SCIENCE BV, 2008)
Interleukin-22 (IL-22) is a member of the interleukin-10 cytokine family, which is involved in anti-microbial defenses, tissue damage protection and repair, and acute phase responses. Its signaling mechanism involves the ...
Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22
(ELSEVIER SCIENCE BV, 2009)
Interleukin-22 (IL-22) plays an important role in the regulation of immune and inflammatory responses in mammals. The IL-22 binding protein (IL-22BP), a soluble receptor that specifically binds IL-22, prevents the ...
Combined in vitro il-12 and il-15 stimulation promotes cellular immune response in dogs with visceral leishmaniasis
(2020-01-01)
Domestic dogs are the main reservoir of Leishmania infantum, a causative agent of visceral leishmaniasis (VL). The number of human disease cases is associated with the rate of canine infection. Currently available drugs ...
Association between genetic polymorphisms of interleukin 6 (IL6), IL6R and IL18 with metabolic syndrome in obese Chilean children Polimorfismos genéticos de interleuquina 6 (IL6), IL6R e IL18: Asociación con componentes del síndrome metabólico en niños ch
(Sociedad Medica de Santiago, 2014)
Background: Metabolic Syndrome (MS) is highly prevalent among obese children and adolescents and is considered a predictor for the development of type 2 diabetes mellitus and cardiovascular disease. Obesity is associated ...
Interleukin-4 and interleukin-13 inhibit the expression of leukemia inhibitory factor and interleukin-11 in fibroblasts
(Pergamon-Elsevier B.V. Ltd, 2012-01-01)
Cytokines produced by inflammatory or resident mesenchymal cells play important modulatory roles in the pathogenesis of inflammation induced bone loss. In the present study, the effects of IL-4 and IL-13 on the expression ...
Severity of COPD and its relationship with IL-10
(2018-06-01)
Background: The present study was designed to compare inflammatory and metabolic responses according to severity of airflow among patients with COPD and to verify the relationship between pulmonary function, body composition, ...