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Angiotensin I-converting enzyme gene polymorphism influences chronic hypertensive response in the rat Goldblatt model
(LIPPINCOTT WILLIAMS & WILKINS, 2002-03)
Background and objective In humans, the insertion/ deletion polymorphism in the anglotensin (Ang) I converting enzyme (ACE) gene significantly determines ACE activity. The deletion allele induces higher ACE levels and is ...
Rat kidney antioxidant response to long-term exposure to flavonol rich red wine
(2002)
This study evaluated the antioxidant defense system of the rat kidney following chronic exposure to red wine rich in flavonols. Both ethanol and antioxidant non-alcoholic wine components, mainly polyphenols, could contribute ...
Physiological adaptations of yeasts living in cold environments and their potential applications
(Springer, 2015)
Yeasts, widely distributed across the Earth, have successfully colonized cold environments despite their adverse conditions for life. Lower eukaryotes play important ecological roles, contributing to nutrient recycling and ...
Changes in (Na + K)-adenosine triphosphatase activity and ultrastructure of lung and kidney associated with oxidative stress induced by acute ethanol intoxication
(2002)
Study and objectives: (Na + K)-adenosine triphosphatase (ATPase) activity, oxidative stress parameters, and morphologic characteristics of the lung and kidney of rats under acute ethanol intoxication were assessed to ...
Phosphoglycerate kinase: structural aspects and functions, with special emphasis on the enzyme from Kinetoplastea
(Royal Society, 2020)
Phosphoglycerate kinase (PGK) is a glycolytic enzyme that is well conserved among the three domains of life. PGK is usually a monomeric enzyme of about 45 kDa that catalyses one of the two ATP-producing reactions in the ...
Expression, purification, and biochemical characterization of recombinant DNA polymerase beta of the Trypanosoma cruzi TcI lineage: requirement of additional factors and detection of phosphorylation of the native form
(Springer, 2015)
Chagas disease, caused by the protozoan
Trypanosoma cruzi, is a major parasitic disease that affects
millions of people in America. However, despite the high
impact of this disease on human health, no effective and ...
Identifying Sequential Substrate Binding at the Single-Molecule Level by Enzyme Mechanical Stabilization
(ACS Publications, 2015)
Enzyme-substrate binding is a dynamic process intimately coupled to protein structural changes, which in turn changes the unfolding energy landscape. By the use of single-molecule force spectroscopy (SMFS), we characterize ...
Kinetic mechanism of phosphofructokinase-2 from Escherichia coli. A mutant enzyme with a different mechanism
(1984)
The kinetic mechanisms of Escherichia coli phosphofructokinase-2 (Pfk-2) and of the mutant enzyme Pfk-2* were investigated. Initial velocity studies showed that both enzymes have a sequential kinetic mechanism, indicating ...