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Role of nitric oxide in the local and systemic pathophysiological effects induced by Bothrops asper snake venom in mice
(2006)
Objective
To assess the role of nitric oxide in the most relevant local and systemic manifestations in mice injected with the venom of the snake Bothrops asper. Mice were pretreated with nitric oxide synthase inhibitors, ...
Local tissue damage induced by Bothrops snake venoms - A review
(1989-12)
This review focuses on the local effects induced by Bothrops venoms. These envenomation are characterized by myonecrosis, hemorrhage and edema which develop rapidly after venom inoculation. Myonecrosis is caused (a) directly, ...
Local effects induced by coral snake venoms: Evidence of myonecrosis after experimental inoculations of venoms from five species
(1983)
The local effects induced by intramuscular inoculations of venons from six species of coral snakes were studied in mice. Venoms of Micrurus nlgrocinctus nigrocinctus, M. n . moquitensis, M. alleni, M. frontalis, M. aarinkauda ...
Pathogenesis of myonecrosis induced by coral snake (Micrurus nigrocinctus) venom in mice
(1986-02)
The mode by which coral snake (Micrurus nigrocinctus) venom affects skeletal muscle was studied using a combined approach. The venom induced early functional and structural alterations in the plasma membrane of muscle ...
Understanding and confronting snakebite envenoming: The harvest of cooperation
(2016-01)
During 45 years, the Instituto Clodomiro Picado (ICP, University of Costa Rica) has developed an ambitious scientific, technological, productive, and social program aimed at providing a better understanding of snakes and ...
Snake venom Lys49 myotoxins: from phospholipases A2 to non-enzymatic membrane disruptors
(2012-09)
Snake venoms often contain toxins that cause a rapid necrosis of skeletal muscle fibers,
referred to as myotoxins. The most common among them are phospholipases A2 (PLA2s),
enzymes that have two independent evolutionary ...
Effects of neutrophil depletion in the local pathological alterations and muscle regeneration in mice injected with Bothrops jararaca snake venom
(2005-04)
In order to study the role of neutrophils in the acute local pathological alterations induced by Bothrops jararaca snake venom, and in the process of skeletal muscle regeneration that follows, an experimental model was ...
Neutralization of myonecrosis, hemorrhage, and edema induced by Bothrops asper snake venom by homologous and heterologous pre-existing antibodies in mice
(1996)
The ability of pre-existing antibodies to neutralize locally-acting toxins of Bothrops
asper snake venom was investigated. Hemorrhage, myonecrosis, and edema
were markedly reduced in actively immunized mice, although ...
Role of TNF-α, IL-1β and IL-6 in the local tissue damage induced by Bothrops asper snake venom: an experimental assessment in mice
(2005-02)
The role of the cytokines TNF-α, IL-1β and IL-6 in the acute local pathological effects induced by Bothrops asper snake venom was assessed in mice. Intramuscular injection of this venom induced increments in IL-1β and IL-6 ...
An MTT-based method for the in vivo quantification of myotoxic activity of snake venoms and its neutralization by antibodies
(1993-05)
The reduction of the tetrazolium compound MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide) was used as the basis for the development of a simple method for the quantitative estimation of metabolically ...