Energy Metabolism in Cardiac Remodeling and Heart Failure
Cardiology in Review, v. 21, n. 3, p. 135-140, 2013.
Gaiolla, Paula Schmidt Azevedo
Minicucci, Marcos Ferreira
Santos, Priscila P.
Paiva, Sergio Alberto Rupp de
Zornoff, Leonardo Antonio Mamede
Fatty acids are the main substrates used by mitochondria to provide myocardial energy under normal conditions. During heart remodeling, however, the fuel preference switches to glucose. In the earlier stages of cardiac remodeling, changes in energy metabolism are considered crucial to protect the heart from irreversible damage. Furthermore, low fatty acid oxidation and the stimulus for glycolytic pathway lead to lipotoxicity, acidosis, and low adenosine triphosphate production. While myocardial function is directly associated with energy metabolism, the metabolic pathways could be potential targets for therapy in heart failure. © 2013 by Lippincott Williams & Wilkins.
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Universidade Estadual Paulista (UNESP); Faculdade de Medicina (2013-05-01)Fatty acids are the main substrates used by mitochondria to provide myocardial energy under normal conditions. During heart remodeling, however, the fuel preference switches to glucose. In the earlier stages of cardiac ...
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