Energy Metabolism in Cardiac Remodeling and Heart Failure

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorGaiolla, Paula Schmidt Azevedo
dc.creatorMinicucci, Marcos Ferreira
dc.creatorSantos, Priscila P.
dc.creatorPaiva, Sergio Alberto Rupp de
dc.creatorZornoff, Leonardo Antonio Mamede
dc.date2014-05-27T11:29:02Z
dc.date2016-10-25T18:48:00Z
dc.date2014-05-27T11:29:02Z
dc.date2016-10-25T18:48:00Z
dc.date2013-05-01
dc.date.accessioned2017-04-06T02:22:20Z
dc.date.available2017-04-06T02:22:20Z
dc.identifierCardiology in Review, v. 21, n. 3, p. 135-140, 2013.
dc.identifier1061-5377
dc.identifier1538-4683
dc.identifierhttp://hdl.handle.net/11449/75251
dc.identifierhttp://acervodigital.unesp.br/handle/11449/75251
dc.identifier10.1097/CRD.0b013e318274956d
dc.identifierWOS:000317590000004
dc.identifier2-s2.0-84876408688
dc.identifierhttp://dx.doi.org/10.1097/CRD.0b013e318274956d
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/895998
dc.descriptionFatty acids are the main substrates used by mitochondria to provide myocardial energy under normal conditions. During heart remodeling, however, the fuel preference switches to glucose. In the earlier stages of cardiac remodeling, changes in energy metabolism are considered crucial to protect the heart from irreversible damage. Furthermore, low fatty acid oxidation and the stimulus for glycolytic pathway lead to lipotoxicity, acidosis, and low adenosine triphosphate production. While myocardial function is directly associated with energy metabolism, the metabolic pathways could be potential targets for therapy in heart failure. © 2013 by Lippincott Williams & Wilkins.
dc.languageeng
dc.relationCardiology in Review
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectβ-oxidation
dc.subjectcardiac failure
dc.subjectenergy metabolism
dc.subjectglycolysis
dc.subjectheart remodeling
dc.subjectmitochondrial dysfunction
dc.subjectadenosine triphosphate
dc.subjectglucose transporter 1
dc.subjectglucose transporter 4
dc.subjectlactate dehydrogenase
dc.subjectprotein kinase B
dc.subjectranolazine
dc.subjectbioavailability
dc.subjectcarbohydrate metabolism
dc.subjectcell damage
dc.subjectcitric acid cycle
dc.subjectenergy yield
dc.subjectesterification
dc.subjectfatty acid oxidation
dc.subjectglucose oxidation
dc.subjectglucose transport
dc.subjectheart failure
dc.subjectheart function
dc.subjectheart muscle metabolism
dc.subjectheart ventricle remodeling
dc.subjecthuman
dc.subjectlipid storage
dc.subjectlipotoxicity
dc.subjectmetabolism
dc.subjectmitochondrial dynamics
dc.subjectmitochondrial membrane
dc.subjectoxidative phosphorylation
dc.subjectoxidative stress
dc.subjectoxygen consumption
dc.subjectprotein dephosphorylation
dc.subjectrespiratory chain
dc.subjectreview
dc.subjectsarcoplasmic reticulum
dc.subjectupregulation
dc.subjectAdenosine Triphosphate
dc.subjectChronic Disease
dc.subjectEnergy Metabolism
dc.subjectHeart
dc.subjectHeart Failure
dc.subjectHumans
dc.subjectMitochondria, Heart
dc.subjectMitochondrial Diseases
dc.subjectMyocardium
dc.subjectNitric Oxide
dc.subjectOxidation-Reduction
dc.titleEnergy Metabolism in Cardiac Remodeling and Heart Failure
dc.typeOtro


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