Comparison of the First and Second Wave of Infections by SARS-CoV-2: A Retrospective and Longitudinal Study From a Primary Health Care Center in Santiago of Chile

dc.creatorAcuña-Castillo, Claudio
dc.creatorInostroza-Molina, Ailen
dc.creatorCastro, Sergio A.
dc.creatorMolina-Cabrera, Sonia
dc.creatorLeiva-Salcedo, Elías
dc.creatorRiquelme, Denise
dc.creatorLuraschi, Roberto
dc.creatorBarrera-Avalos, Carlos
dc.creatorVallejos-Vidal, Eva
dc.creatorMella-Torres, Andrea
dc.creatorValdés, Daniel
dc.creatorTorres, Claudio
dc.creatorMaisey, Kevin
dc.creatorEscobar, Alejandro
dc.creatorReyes-Cerpa, Sebastián
dc.creatorToro-Ascuy, Daniela
dc.creatorImarai, Mónica
dc.creatorReyes-López, Felipe E.
dc.creatorSandino, Ana María
dc.date2024-04-10T05:53:52Z
dc.date2024-04-10T05:53:52Z
dc.date2022
dc.date.accessioned2024-07-17T21:15:31Z
dc.date.available2024-07-17T21:15:31Z
dc.identifier10.3389/fpubh.2022.913519
dc.identifier22962565
dc.identifierhttps://hdl.handle.net/20.500.12728/10846
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9509855
dc.descriptionThe current COVID-19 pandemic is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Many countries have reported the experience of at least two contagion waves, describing associated mortality rates and population behavior. The analysis of the effect of this pandemic in different localities can provide valuable information on the key factors to consider in the face of future massive infectious diseases. This work describes the first retrospective and comparative study about behavior during the first and second waves of the COVID-19 pandemic in Chile from a primary Healthcare Center. From 19,313 real-time quantitative PCR (RT-qPCR) tests assessed, the selected 1,694 positive diagnostics showed a decrease in mortality rate in the second wave (0.6%) compared with the first (4.6%). In addition, we observed that infections in the second wave were mainly in young patients with reduced comorbidities. The population with a complete vaccination schedule shows a decrease in the duration of symptoms related to the disease, and patients with more comorbidities tend to develop severe illness. This report provides evidence to partially understand the behavior and critical factors in the severity of the COVID-19 pandemic in the population of Santiago of Chile. Copyright © 2022 Acuña-Castillo, Inostroza-Molina, Castro, Molina-Cabrera, Leiva-Salcedo, Riquelme, Luraschi, Barrera-Avalos, Vallejos-Vidal, Mella-Torres, Valdés, Torres, Maisey, Escobar, Reyes-Cerpa, Toro-Ascuy, Imarai, Reyes-López and Sandino.
dc.descriptionDICYT-USACH; FONDEQUIP, (CEDENNA AFB-180001, EQM200016); American Medical Systems, AMS; Ministry of Health, MOH, (COVID-19, COVID1038); Fondo Nacional de Desarrollo Científico y Tecnológico, FONDECYT, (11221308, 1201664, 1211841); Departamento de Investigaciones Científicas y Tecnológicas, Universidad de Santiago de Chile, DICYT, (021943AC); Agencia Nacional de Investigación y Desarrollo, ANID
dc.formatapplication/pdf
dc.languageen
dc.publisherFrontiers Media S.A.
dc.subjectChile
dc.subjectCOVID-19
dc.subjectSARS-CoV-2
dc.subjectvaccination
dc.subjectwaves of infection
dc.titleComparison of the First and Second Wave of Infections by SARS-CoV-2: A Retrospective and Longitudinal Study From a Primary Health Care Center in Santiago of Chile
dc.typeArticle


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