MicroRNAs as Potential Biomarkers of Environmental Exposure to Polycyclic Aromatic Hydrocarbons and Their Link with Inflammation and Lung Cancer

dc.creatorLetelier, Pablo
dc.creatorSaldías, Rolando
dc.creatorLoren, Pía
dc.creatorRiquelme, Ismael
dc.creatorGuzmán, Neftalí
dc.date2024-04-10T01:30:25Z
dc.date2024-04-10T01:30:25Z
dc.date2023
dc.date.accessioned2024-07-17T21:15:06Z
dc.date.available2024-07-17T21:15:06Z
dc.identifier10.3390/ijms242316984
dc.identifier16616596
dc.identifierhttps://hdl.handle.net/20.500.12728/10615
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9509790
dc.descriptionExposure to atmospheric air pollution containing volatile organic compounds such as polycyclic aromatic hydrocarbons (PAHs) has been shown to be a risk factor in the induction of lung inflammation and the initiation and progression of lung cancer. MicroRNAs (miRNAs) are small single-stranded non-coding RNA molecules of ~20–22 nucleotides that regulate different physiological processes, and their altered expression is implicated in various pathophysiological conditions. Recent studies have shown that the regulation of gene expression of miRNAs can be affected in diseases associated with outdoor air pollution, meaning they could also be useful as biomarkers of exposure to environmental pollution. In this article, we review the published evidence on miRNAs in relation to exposure to PAH pollution and discuss the possible mechanisms that may link these compounds with the expression of miRNAs. © 2023 by the authors.
dc.descriptionDIUAV, (03-2022); VVIPUCT, (2023FIAS-PL-03, VIPUCT-2022REG-NG-01); Vicerrectoría de Investigación y Postgrado; Universidad Autónoma de Coahuila, UAdeC; Universidad Católica de Temuco, UCT
dc.formatapplication/pdf
dc.languageen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.subjectlung cancer
dc.subjectmicroRNAs
dc.subjectparticulate matter
dc.subjectpolycyclic aromatic hydrocarbons
dc.subjectpulmonary cancer
dc.titleMicroRNAs as Potential Biomarkers of Environmental Exposure to Polycyclic Aromatic Hydrocarbons and Their Link with Inflammation and Lung Cancer
dc.typeArticle


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