Comparative Effect of Two Types of Physical Exercise for the Improvement of Exercise Capacity, Diastolic Function, Endothelial Function and Arterial Stiffness in Participants with Heart Failure with Preserved Ejection Fraction (ExIC-FEp Study): Protocol for a Randomized Controlled Trial

dc.creatorCavero-Redondo, Iván
dc.creatorSaz-Lara, Alicia
dc.creatorMartínez-García, Irene
dc.creatorBizzozero-Peroni, Bruno
dc.creatorDíaz-Goñi, Valentina
dc.creatorDíez-Fernández, Ana
dc.creatorMoreno-Herráiz, Nerea
dc.creatorPascual-Morena, Carlos
dc.date2024-04-10T00:10:13Z
dc.date2024-04-10T00:10:13Z
dc.date2023
dc.date.accessioned2024-07-17T21:14:50Z
dc.date.available2024-07-17T21:14:50Z
dc.identifier10.3390/jcm12103535
dc.identifier20770383
dc.identifierhttps://hdl.handle.net/20.500.12728/10394
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9509749
dc.description(1) Background: Heart failure (HF) with preserved ejection fraction (HFpEF) accounts for approximately 50% of all patients with HF. In the absence of pharmacological treatments that have been successful in reducing mortality or morbidity in this pathology, physical exercise is recognized as an important adjunct in the treatment of HF. Therefore, the objective of this study is to compare the efficacy of combined training and high intensity interval training (HIIT) on exercise capacity, diastolic function, endothelial function, and arterial stiffness in participants with HFpEF. (2) Methods: The ExIC-FEp study will be a single-blind, 3-arm, randomized clinical trial (RCT) conducted at the Health and Social Research Center of the University of Castilla-La Mancha. Participants with HFpEF will be randomly assigned (1:1:1) to the combined exercise, HIIT or control group to evaluate the efficacy of physical exercise programs on exercise capacity, diastolic function, endothelial function, and arterial stiffness. All participants will be examined at baseline, at three months and at six months. (3) Results: The findings of this study will be published in a peer-reviewed journal. (4) Conclusions: This RCT will represent a significant advance in the available scientific evidence on the efficacy of physical exercise in the treatment of HFpEF. © 2023 by the authors.
dc.descriptionConsejería de Educación, Cultura y Deportes—Junta de Comunidades de Castilla–La Mancha; University Ministry, (2022-PRED-21183); European Social Fund, ESF, (2018-CPUCLM-7939, 2020-PREDUCLM-16746); Universidad de Castilla-La Mancha, UCLM; European Regional Development Fund, ERDF, (SBPLY/21/180501/000112)
dc.formatapplication/pdf
dc.formatapplication/octet-stream
dc.languageen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.subjectarterial stiffness
dc.subjectdiastolic function
dc.subjectendothelial function
dc.subjectexercise capacity
dc.subjectheart failure
dc.subjectphysical exercise
dc.titleComparative Effect of Two Types of Physical Exercise for the Improvement of Exercise Capacity, Diastolic Function, Endothelial Function and Arterial Stiffness in Participants with Heart Failure with Preserved Ejection Fraction (ExIC-FEp Study): Protocol for a Randomized Controlled Trial
dc.typeArticle


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