Exploring the Influence of Insulin Resistance on Arterial Stiffness in Healthy Adults: From the Metabolic and Cardiovascular Health Insights of the EVasCu Study

dc.creatorPascual-Morena, Carlos
dc.creatorCavero-Redondo, Iván
dc.creatorMartínez-García, Irene
dc.creatorRodríguez-Gutiérrez, Eva
dc.creatorLucerón-Lucas-Torres, Maribel
dc.creatorMoreno-Herráiz, Nerea
dc.creatorDíaz-Goñi, Valentina
dc.creatorSaz-Lara, Alicia
dc.date2024-06-21T20:16:48Z
dc.date2024-06-21T20:16:48Z
dc.date2024
dc.date.accessioned2024-07-17T21:13:26Z
dc.date.available2024-07-17T21:13:26Z
dc.identifier10.3390/nu16060791
dc.identifier20726643
dc.identifierhttps://hdl.handle.net/20.500.12728/11523
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9509507
dc.descriptionPrevious evidence associates insulin resistance with arterial stiffness in various pathologies, yet limited reports exist in healthy adults. Therefore, this study aims to estimate the association between insulin resistance and arterial stiffness in healthy adults. The cross-sectional EVasCu study enrolled 390 participants (42.05 ± 13.15 years). ANCOVAs, unadjusted (model 1) and adjusted (model 2), explored the association between arterial stiffness markers (aortic Pulse Wave Velocity [aPWV], Augmentation Index [AIx@75] and Cardio-Ankle Vascular Index [CAVI]), and insulin resistance markers (Homeostasis Model Assessment of Insulin Resistance [HOMA-IR], Quantitative Insulin Sensitivity Check Index [QUICKI] and Triglycerides-Glucose [TyG]). In model 1, all insulin resistance markers were associated with aPWV, HOMA-IR and QUICKI were associated with AIx@75, and the TyG index was associated with CAVI. In model 2, HOMA-IR and QUICKI increased aPWV by 0.179 and 0.156 m/s (p = 0.001 and p = 0.011), and AIx@75 by 4.17 and 5.39% (p = 0.009 and p = 0.003). The EVasCu study offers valuable insights into the relationship between insulin resistance and arterial stiffness in healthy adults, providing a deeper understanding of metabolic and cardiovascular health. By examining this influence, we embark on an intriguing exploration of how these factors interplay in the human body. © 2024 by the authors.
dc.descriptionUniversidad Pontificia Comillas and Escuela de Enfermería y Fisioterapia San Juan de Dios; Universidad de Castilla-La Mancha, UCLM, (2018-CPUCLM-7939); Ministerio de Ciencia, Innovación y Universidades, MCIU, (FPU21/06866, 2022-PROD-20657)
dc.formatapplication/pdf
dc.formatapplication/octet-stream
dc.languageen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.subjectadult
dc.subjectcardiovascular health
dc.subjectendocrinology
dc.subjectepidemiology
dc.subjectinsulin resistance
dc.subjectmetabolism
dc.subjectpulse wave analysis
dc.subjectvascular stiffness
dc.titleExploring the Influence of Insulin Resistance on Arterial Stiffness in Healthy Adults: From the Metabolic and Cardiovascular Health Insights of the EVasCu Study
dc.typeArticle


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