Wettability of Amino Acid-Functionalized PSMA Electrospun Fibers for the Modulated Release of Active Agents and Its Effect on Their Bioactivity

dc.creatorSantander, Sebastián
dc.creatorPadilla-Manzano, Nicolás
dc.creatorDíaz, Bastián
dc.creatorBacchiega, Renato
dc.creatorJara, Elizabeth
dc.creatorÁlvarez, Luis Felipe
dc.creatorPinto, Cristóbal
dc.creatorForero, Juan C.
dc.creatorSantana, Paula
dc.creatorHamm, Eugenio
dc.creatorUrzúa, Marcela
dc.creatorTamayo, Laura
dc.date2024-04-10T01:36:16Z
dc.date2024-04-10T01:36:16Z
dc.date2023
dc.date.accessioned2024-07-17T21:10:40Z
dc.date.available2024-07-17T21:10:40Z
dc.identifier10.3390/pharmaceutics15061659
dc.identifier19994923
dc.identifierhttps://hdl.handle.net/20.500.12728/10637
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9508931
dc.descriptionThe ideal treatment for chronic wounds is based on the use of bioactive dressings capable of releasing active agents. However, the control of the rate at which these active agents are released is still a challenge. Bioactive polymeric fiber mats of poly(styrene-co-maleic anhydride) [PSMA] functionalized with amino acids of different hydropathic indices and L-glutamine, L-phenylalanine and L-tyrosine levels allowed obtaining derivatives of the copolymers named PSMA@Gln, PSMA@Phe and PSMA@Tyr, respectively, with the aim of modulating the wettability of the mats. The bioactive characteristics of mats were obtained by the incorporation of the active agents Calendula officinalis (Cal) and silver nanoparticles (AgNPs). A higher wettability for PSMA@Gln was observed, which is in accordance with the hydropathic index value of the amino acid. However, the release of AgNPs was higher for PSMA and more controlled for functionalized PSMA (PSMAf), while the release curves of Cal did not show behavior related to the wettability of the mats due to the apolar character of the active agent. Finally, the differences in the wettability of the mats also affected their bioactivity, which was evaluated in bacterial cultures of Staphylococcus aureus ATCC 25923 and methicillin-resistant Staphylococcus aureus ATCC 33592, an NIH/3T3 fibroblast cell line and red blood cells. © 2023 by the authors.
dc.descriptionANID-Chile; Fondo Nacional de Desarrollo Científico y Tecnológico, FONDECYT, (1191467, 1200853, 1231631)
dc.formatapplication/pdf
dc.formatapplication/octet-stream
dc.languageen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.subjectamino acid
dc.subjectelectrospinning
dc.subjectfibers
dc.subjectfunctionalization
dc.subjectrelease
dc.subjectwettability
dc.titleWettability of Amino Acid-Functionalized PSMA Electrospun Fibers for the Modulated Release of Active Agents and Its Effect on Their Bioactivity
dc.typeArticle


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