Tracking between cardiovascular-related measures at 4 and 8 years of age in the INMA-Asturias cohort

dc.creatorFernández-Iglesias, Rocío
dc.creatorMartinez-Camblor, Pablo
dc.creatorFernández-Somoano, Ana
dc.creatorRodríguez-Dehli, Cristina
dc.creatorVenta-Obaya, Rafael
dc.creatorKaragas, Margaret R.
dc.creatorTardón, Adonina
dc.creatorRiaño-Galán, Isolina
dc.date2024-04-09T23:22:33Z
dc.date2024-04-09T23:22:33Z
dc.date2023
dc.date.accessioned2024-07-17T21:10:29Z
dc.date.available2024-07-17T21:10:29Z
dc.identifier10.1007/s00431-023-05051-8
dc.identifier03406199
dc.identifierhttps://hdl.handle.net/20.500.12728/10376
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9508883
dc.descriptionIdentifying cardiovascular-related measures that track from early childhood into later ages may help inform early prevention targets for cardiovascular disease. In this study, the tracking of triglycerides (TG), high-density cholesterol (HDL-c), atherogenic coefficient (AC), waist circumference to height ratio (WC/Height), mean arterial pressure (MAP), and homeostatic model assessment of insulin resistance (HOMA-IR) was examined in the INMA-Asturias cohort between 4 and 8 years of age. The analysis was conducted in 307 children who participated in the INMA-Asturias cohort (Spain) at 4 and at 8 years of age. Quantile regression models were used to evaluate tracking between measures at both ages, with each measure at 8 years as the dependent variable and the rank transformation of the same measure at 4 years as the independent variable. We found a positive association between HDL-c rank at 4 years and higher quantiles of the HDL-c distribution at 8 years, with an increase of 2.93 mg/dL (95% CI: 1.98, 3.87) per decile in the 0.9 quantile. A positive association was also found for WC/Height, with an increase of 0.008 (95% CI: 0.004, 0.012) per decile in the 0.9 quantile. We observed that tracking for AC increased in the higher quantiles of the distribution at 8 years, with an increase of 0.11 (95% CI: 0.09, 0.14) in the 0.6 quantile compared to an effect of 0.15 (95% CI: 0.09, 0.21) in the 0.9 quantile. Conclusions: Adult markers of dyslipidemia and central obesity tracked between ages 4 and 8 years. For AC, tracking increased in the higher quantiles of the distribution. What is Known: • Atherosclerosis begins in early life, so preventive efforts that start in childhood may delay progression to clinical disease. Determine what cardiovascular risk factors track into time since childhood bring the opportunity to identified those subjects at risk for later cardiovascular disease. • The study of risk factors in health populations and, particularly in children, copes with not clear and/or controversial thresholds definition. This makes it challenging to study tracking in pediatric ages. What is New: • Quantile regression is a useful tool for assessing the tracking of risk factors for which there are no clinically meaningful thresholds. The increasing trend observed in the tracking of dyslipidemia suggests the possible difficulty that children with abnormal values at 4 years of age might have in normalizing them in future years. • The findings of this article may help to determine which cardiovascular-related measures could be screened and followed-up in children. © 2023, The Author(s).
dc.descriptionCIBERESP, (abroad-2022); Fundación Bancaria Caja de Ahorros de Asturias; Federación Española de Enfermedades Raras, FEDER; Instituto de Salud Carlos III, ISCIII, (PI04/2018, PI09/02311, PI13/02429, PI18/00909); Universidad de Oviedo; European Regional Development Fund, ERDF; pediatrics services of Hospital San Agustín
dc.formatapplication/pdf
dc.languageen
dc.publisherSpringer Science and Business Media Deutschland GmbH
dc.subjectCardiovascular risk
dc.subjectChildhood
dc.subjectDyslipidemia
dc.subjectHyperglycemia
dc.subjectHypertension
dc.subjectObesity
dc.subjectQuantile regression
dc.subjectTracking
dc.titleTracking between cardiovascular-related measures at 4 and 8 years of age in the INMA-Asturias cohort
dc.typeArticle


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