Human Platelet Polymorphism can be a genetic marker associated with HIV/HCV coinfection

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorGrotto, Rejane Maria Tommasini
dc.creatorPicelli, Natália
dc.creatorSouza, Lenice do Rosário de
dc.creatorSilva, Giovanni Faria
dc.creatorFerrasi, Adriana Camargo
dc.creatorSilveira, Liciana Vaz de Arruda
dc.creatorPardini, Maria Inês de Moura Campos
dc.date2015-12-07T15:31:34Z
dc.date2016-10-25T21:22:43Z
dc.date2015-12-07T15:31:34Z
dc.date2016-10-25T21:22:43Z
dc.date2015
dc.date.accessioned2017-04-06T09:27:26Z
dc.date.available2017-04-06T09:27:26Z
dc.identifierJournal Of Medical Virology, v. 87, n. 10, p. 1677-1681, 2015.
dc.identifier1096-9071
dc.identifierhttp://hdl.handle.net/11449/131097
dc.identifierhttp://acervodigital.unesp.br/handle/11449/131097
dc.identifier10.1002/jmv.24233
dc.identifier25976501
dc.identifierhttp://dx.doi.org/10.1002/jmv.24233
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/941637
dc.descriptionTo evaluate the associations of HPA polymorphisms -1, -3, and -5 with HIV/HCV coinfection were included in this study 60 HIV/HCV-coinfected patients from the Sao Paulo State health service centers. Data reported by Verdichio-Moraes et al. (2009: J. Med Virol 81:757-759) were used as the non-infected and HCV monoinfected groups. Human Platelet Polymorphism genotyping was performed in 60 Patients co-infected with HIV/HCV by PCR-SSP or PCR-RFLP. HIV subtyping and HCV genotyping was performed by RT-PCR followed sequencing. The data analyses were performed using the χ2 test or Fisher's Exact Test and the logistic regression model. Patients coinfected with HIV/HCV presented HCV either genotype 1 (78.3%) or non-1 (21.7%) and HIV either subtype B (85.0%) or non-B (15%). The Human Platelet Polymorphism-1a/1b genotype was more frequent (P < 0.05) in HIV/HCV coinfection than in HCV monoinfection and the allelic frequency of Human Platelet Polymorphism-5b in the Patients coinfected with HIV/HCV was higher (P < 0.05) than in HCV monoinfected cases and non-infected individuals. These data suggest that the presence of specific HPA allele on platelets could favor the existence of coinfection. On the other hand, Human Platelet Polymorphism-5a/5b was more frequent (P < 0.05) in HIV/HCV coinfected and HCV monoinfected groups than in the non-infected individuals, suggesting that this platelet genotype is related to HCV infection, regardless of HIV presence. Results suggest that the Human Platelet Polymorphism profile in HIV/HCV coinfected individuals differs from the one of both HCV monoinfected and non-infected population. So, the Human Platelet Polymorphism can be a genetic marker associated with HIV/HCV coinfection.
dc.languageeng
dc.publisherWiley-Blackwell
dc.relationJournal Of Medical Virology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHIV/HVC coinfection
dc.subjectHuman platelet polymorphism -1
dc.subjectHuman platelet polymorphism -3
dc.subjectHuman platelet polymorphism -5
dc.subjectPolymorphism
dc.titleHuman Platelet Polymorphism can be a genetic marker associated with HIV/HCV coinfection
dc.typeOtro


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