Morphology of ileal and jejunal pouches used as rectal substitutes

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorTeixeira, Fabio V.
dc.creatorDaud, Danilo
dc.creatorEleuterio, Maria L.
dc.creatorSilva, Maeli D. P.
dc.creatorKelly, Keith A.
dc.date2014-05-20T15:22:40Z
dc.date2016-10-25T21:21:15Z
dc.date2014-05-20T15:22:40Z
dc.date2016-10-25T21:21:15Z
dc.date2003-03-01
dc.date.accessioned2017-04-06T09:22:16Z
dc.date.available2017-04-06T09:22:16Z
dc.identifierDiseases of the Colon and Rectum, v. 46, n. 3, p. 373-376, 2003.
dc.identifier0012-3706
dc.identifierhttp://hdl.handle.net/11449/130476
dc.identifierhttp://acervodigital.unesp.br/handle/11449/130476
dc.identifier10.1007/s10350-004-6558-5
dc.identifierWOS:000181631500014
dc.identifier2-s2.0-0037342254
dc.identifierhttp://dx.doi.org/10.1007/s10350-004-6558-5
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/941019
dc.descriptionPURPOSE: Our aim was to determine whether the mucosa of a canine jejunal pouch used as a rectal substitute after proctocolectomy retains its morphologic features better than the mucosa of a canine ileal pouch so used. METHODS: Among ten dogs that underwent proctocolectomy, five had a jejunal pouch-distal rectal anastomosis and five an ileal pouch-distal rectal anastomosis. After six months, the animals were killed, the intestinal pouches and portions of unaltered distal ileum were removed, and a blinded, mucosal morphometric analysis was performed. RESULTS: The mucosa of the jejunal pouches had an overall thickness (mean ± standard deviation, anterior and posterior walls, 1,300 ± 140 μm), villous height (286 ± 46 μm), and crypt depth (790 ± 77 μm) greater than that of the ileal pouches (920 ± 170, 208 ± 47, and 530 ± 130 μm, respectively; P < 0.05). Moreover, the mucosal thickness of the jejunal pouches was similar to that of the distal ileum proximal to the pouch (1,200 ± 200 μm; P > 0.05), whereas the mucosal thickness of the ileal pouch was thinner (P < 0.05). CONCLUSIONS: The jejunal mucosa retains its major morphometric features when the jejunum is used as a rectal substitute after proctocolectomy. In contrast, the ileal mucosa atrophies when the ileum is so used.
dc.publisherLippincott Williams & Wilkins
dc.relationDiseases of the Colon and Rectum
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectIleal pouch-anal canal anastomosis
dc.subjectJejunal pouch-anal canal anastomosis
dc.subjectProctocolectomy
dc.subjectAnimal cell
dc.subjectAnimal experiment
dc.subjectAnimal tissue
dc.subjectControlled study
dc.subjectDog
dc.subjectFemale
dc.subjectIleoanal anastomosis
dc.subjectIleum pouch
dc.subjectIntestine crypt
dc.subjectIntestine metaplasia
dc.subjectIntestine mucosa
dc.subjectIntestine villus
dc.subjectJejunum
dc.subjectJejunum pouch
dc.subjectMorphometrics
dc.subjectNonhuman
dc.subjectProctocolectomy
dc.subjectProsthesis
dc.subjectRectum prosthesis
dc.subjectAnimals
dc.subjectColonic Pouches
dc.subjectDogs
dc.subjectFemale
dc.subjectIntestinal Mucosa
dc.subjectModels, Animal
dc.subjectProctocolectomy, Restorative
dc.titleMorphology of ileal and jejunal pouches used as rectal substitutes
dc.typeOtro


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