Equivalencia química de tabletas de paracetamol de dos formulaciones multifuente frente al producto innovador

Abstract

This study is a descriptive, cross sectional held at the School of Pharmacy and Biochemistry, National University of Trujillo in 2010. The study was conducted in order to determine the chemical equivalence of paracetamol tablets two multisource formulations against innovative product by HPLC (high performance liquid chromatography) established by the USP XXIX. Were acquired from 60 tablets of paracetamol and Generics Natural Laboratories, and GlaxoSmithKline Medifarma Regional Teaching Hospital and a pharmaceutical establishment of the center of Trujillo, on trial for the determination of the amount of that principle. The results were expressed in percentages compared to average and average in the absence of laboratories and laboratory multisource products of the innovator product, being respectively 98.14%, 97.88%, 105.88% and 1.86%, 2.12% - 5.87%, and these values within the ranges set by the USP XXIX, which stipulates that the content of active ingredient Paracetamol tablets should be 90% to 110% as stated by the manufacturer. Concluding that multisource paracetamol tablets are equivalent to the innovator against chemical