dc.creator | Shiffer, Dana | |
dc.creator | Zamunér, Antonio | |
dc.creator | Minonzio, Maura | |
dc.creator | Bulgheroni, Mara | |
dc.creator | Porta, Alberto | |
dc.creator | Leone, Roberto | |
dc.creator | Bottazzi, Barbara | |
dc.creator | Garlanda, Cecilia | |
dc.creator | Colotta, Francesco | |
dc.creator | Barbic, Franca | |
dc.creator | Mantovani, Alberto | |
dc.creator | Furlan, Raffaello | |
dc.date | 2023-10-10T18:36:55Z | |
dc.date | 2023-10-10T18:36:55Z | |
dc.date | 2023 | |
dc.date.accessioned | 2024-05-02T20:31:43Z | |
dc.date.available | 2024-05-02T20:31:43Z | |
dc.identifier | http://repositorio.ucm.cl/handle/ucm/5002 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/9275219 | |
dc.description | Introduction: Systemic inflammation promotes neurodegeneration in Parkinson’s disease (PD). Interleukin-1 receptor type 2 (sIL-1R2) plasma levels increase during inflammation. Data on sIL-1R2 in PD patients and its relationship with PD cardiac autonomic profile are limited, given the possible anti-inflammatory effect of vagal activation. Previously, automated mechanical peripheral somatosensory stimulation (AMPSS) enhanced cardiac vagal modulation. Objectives were to 1) evaluate sIL-1R2 plasma concentrations in PD patients and healthy controls and 2) investigate the correlations between sIL-1R2 and cardiac autonomic indices obtained by spectrum analysis of heart rate variability before and after AMPSS.
Methods: sIL-1R2 plasma levels were assessed in 48 PD patients and 50 healthy controls. Electrocardiogram and beat-by-beat arterial pressure were recorded at baseline and after 5 AMPSS sessions in 16 PD patients.
Results: PD patients had higher sIL-1R2 levels than controls. In the PD subgroup, an inverse correlation between sIL-1R2 and HFnu was found. There was a negative correlation between changes induced by AMPSS on HFnu and sIL-1R2.
Discussion: Higher sIL-1R2 levels in PD patients reflect the inflammatory dysregulation associated with the disease. In PD patients, higher sIL-1R2 was associated with reduced cardiovagal tone. Increased cardiovagal modulation following AMPSS was associated with lower sIL-1R2 levels in Parkinson’s disease patients, suggesting inflammatory state improvement. | |
dc.language | en | |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 Chile | |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 Chile | |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
dc.source | Frontiers in Physiology, 14, 1168652 | |
dc.subject | Soluble interleukin-1 receptor type 2 (sIL-1R2) | |
dc.subject | Cardiovascular autonomic control | |
dc.subject | Parkinson’s disease | |
dc.subject | Mechanical somatosensory stimulation | |
dc.subject | Heart rate variability | |
dc.title | Soluble interleukin-1 receptor type 2 plasma levels in Parkinson’s disease: relationship with cardiac autonomic profile before and after peripheral mechanical somatosensory stimulation | |
dc.type | Article | |