Neuropharmacological modulation of N-methyl-D-aspartate, noradrenaline and endocannabinoid receptors in fear extinction learning: synaptic transmission and plasticity

dc.creatorBattaglia, Simone
dc.creatorDi Fazio, Chiara
dc.creatorVicario, C.M.
dc.creatorAvenanti, Alessio
dc.date2023-04-10T20:53:13Z
dc.date2023-04-10T20:53:13Z
dc.date2023
dc.date.accessioned2024-05-02T20:30:57Z
dc.date.available2024-05-02T20:30:57Z
dc.identifierhttp://repositorio.ucm.cl/handle/ucm/4648
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9274887
dc.descriptionLearning to recognize and respond to potential threats is crucial for survival. Pavlovian threat conditioning represents a key paradigm for investigating the neurobiological mechanisms of fear learning. In this review, we address the role of specific neuropharmacological adjuvants that act on neurochemical synaptic transmission, as well as on brain plasticity processes implicated in fear memory. We focus on novel neuropharmacological manipulations targeting glutamatergic, noradrenergic, and endocannabinoid systems, and address how the modulation of these neurobiological systems affects fear extinction learning in humans. We show that the administration of N-methyl-D-aspartate (NMDA) agonists and modulation of the endocannabinoid system by fatty acid amide hydrolase (FAAH) inhibition can boost extinction learning through the stabilization and regulation of the receptor concentration. On the other hand, elevated noradrenaline levels dynamically modulate fear learning, hindering long-term extinction processes. These pharmacological interventions could provide novel targeted treatments and prevention strategies for fear-based and anxiety-related disorders.
dc.languageen
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.sourceInternational Journal of Molecular Sciences, 24(6), 5926
dc.subjectNeuropharmacology
dc.subjectGlutamatergic receptor N-methyl-D-aspartate (NMDA)
dc.subjectNoradrenaline (NA)
dc.subjectEnzyme fatty acid amide hydrolase (FAAH)
dc.subjectSynaptic receptors
dc.subjectBrain plasticity
dc.subjectFear learning
dc.subjectFear extinction learning
dc.subjectThreat learning
dc.titleNeuropharmacological modulation of N-methyl-D-aspartate, noradrenaline and endocannabinoid receptors in fear extinction learning: synaptic transmission and plasticity
dc.typeArticle


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