| dc.creator | Turrini, Sonia | |
| dc.creator | Bevacqua, Naomi | |
| dc.creator | Cataneo, Antonio | |
| dc.creator | Chiappini, Emilio | |
| dc.creator | Fiori, Francesca | |
| dc.creator | Candidi, Matteo | |
| dc.creator | Avenanti, Alessio | |
| dc.date | 2023-04-04T20:27:56Z | |
| dc.date | 2023-04-04T20:27:56Z | |
| dc.date | 2023 | |
| dc.date.accessioned | 2024-05-02T20:30:52Z | |
| dc.date.available | 2024-05-02T20:30:52Z | |
| dc.identifier | http://repositorio.ucm.cl/handle/ucm/4606 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/9274842 | |
| dc.description | Transcranial magnetic stimulation (TMS) methods such as cortico-cortical paired
associative stimulation (ccPAS) can increase the strength of functional connectivity
between ventral premotor cortex (PMv) and primary motor cortex (M1) via spike
timing-dependent plasticity (STDP), leading to enhanced motor functions in young
adults. However, whether this STDP-inducing protocol is effective in the aging brain
remains unclear. In two groups of young and elderly healthy adults, we evaluated
manual dexterity with the 9-hole peg task before and after ccPAS of the left PMvM1 circuit. We observed that ccPAS enhanced dexterity in young adults, and this effect was anticipated by a progressive increase in motor-evoked potentials (MEPs) during ccPAS administration. No similar effects were observed in elderly individuals
or in a control task. Across age groups, we observed that the magnitude of MEP
changes predicted larger behavioral improvements. These findings demonstrate that
left PMv-to-M1 ccPAS induces functionally specific improvements in young adults’
manual dexterity and an increase in corticomotor excitability, but altered plasticity
prevents the effectiveness of ccPAS in the elderly. | |
| dc.language | en | |
| dc.rights | Atribución-NoComercial-SinDerivadas 3.0 Chile | |
| dc.rights | Atribución-NoComercial-SinDerivadas 3.0 Chile | |
| dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
| dc.source | Frontiers in Aging Neuroscience, 15, 1119508 | |
| dc.subject | TMS | |
| dc.subject | ccPAS | |
| dc.subject | Hebbian plasticity | |
| dc.subject | Manual dexterity | |
| dc.subject | Aging | |
| dc.subject | Motor system | |
| dc.title | Transcranial cortico-cortical paired associative stimulation (ccPAS) over ventral premotor-motor pathways enhances action performance and corticomotor excitability in young adults more than in elderly adults | |
| dc.type | Article | |
