Docosahexaenoic acid and hydroxytyrosol co-administration fully prevents liver steatosis and related parameters in mice subjected to high-fat diet: A molecular approach

dc.creatorSoto-Alarcon, Sandra
dc.creatorOrtiz, Macarena
dc.creatorOrellana, Paula
dc.creatorEcheverría, Francisca
dc.creatorBustamante, Andrés
dc.creatorEspinosa, Alejandra
dc.creatorIllesca, Paola
dc.creatorGonzalez-Mañán, Daniel
dc.creatorValenzuela, Rodrigo
dc.creatorVidela, Luis A.
dc.date2023-01-16T19:18:52Z
dc.date2023-01-16T19:18:52Z
dc.date2019
dc.date.accessioned2024-05-02T20:30:21Z
dc.date.available2024-05-02T20:30:21Z
dc.identifierhttp://repositorio.ucm.cl/handle/ucm/4366
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9274614
dc.descriptionAttenuation of high-fat diet (HFD)-induced liver steatosis is accomplished by different nutritional interventions. Considering that the n-3 PUFA docosahexaenoic acid (DHA) modulates lipid metabolism and the antioxidant hydroxytyrosol (HT) diminishes oxidative stress underlying fatty liver, it is hypothesized that HFD-induced steatosis is suppressed by DHA and HT co-administration. Male C57BL/6J mice were fed a control diet (CD; 10% fat, 20% protein, 70% carbohydrates) or a HFD (60% fat, 20% protein, 20% carbohydrates) for 12 weeks, without and with supplementation of DHA (50 mg/kg/day), HT (5 mg/kg/day) or both. The combined DHA + HT protocol fully prevented liver steatosis and the concomitant pro-inflammatory state induced by HFD, with suppression of lipogenic and oxidative stress signaling, recovery of fatty acid oxidation capacity and enhancement in resolvin availability affording higher inflammation resolution capability. Abrogation of HFD-induced hepatic steatosis by DHA and HT co-administration represents a crucial therapeutic strategy eluding disease progression into stages lacking efficacious handling at present time.
dc.languageen
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.sourceBioFactors, 45(6), 930-943
dc.subjectDocosahexaenoic acid
dc.subjectHydroxytyrosol
dc.subjectLiver steatosis
dc.subjectOxidative stress
dc.subjectPro-inflammatory status
dc.titleDocosahexaenoic acid and hydroxytyrosol co-administration fully prevents liver steatosis and related parameters in mice subjected to high-fat diet: A molecular approach
dc.typeArticle


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