| dc.creator | De la Torre, Alexander F. | |
| dc.creator | Scatena, Gabriel S. | |
| dc.creator | Valdés, Oscar | |
| dc.creator | Rivera, Daniel G. | |
| dc.creator | Paixão, Márcio W. | |
| dc.date | 2023-01-16T19:13:58Z | |
| dc.date | 2023-01-16T19:13:58Z | |
| dc.date | 2019 | |
| dc.date.accessioned | 2024-05-02T20:30:21Z | |
| dc.date.available | 2024-05-02T20:30:21Z | |
| dc.identifier | http://repositorio.ucm.cl/handle/ucm/4361 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/9274610 | |
| dc.description | The multicomponent synthesis of prolyl pseudo-peptide catalysts using the Ugi reaction with furfurylamines or isocyanides is described. The incorporation of such a polymerizable furan handle enabled the subsequent polymerization of the peptide catalyst with furfuryl alcohol, thus rendering polyfurfuryl alcohol-supported catalysts for applications in heterogeneous enamine catalysis. The utilization of the polymer-supported catalysts in both batch and continuous-flow organocatalytic procedures proved moderate catalytic efficacy and enantioselectivity, but excellent diastereoselectivity in the asymmetric Michael addition of n-butanal to β-nitrostyrene that was used as a model reaction. This work supports the potential of multicomponent reactions towards the assembly of catalysts and their simultaneous functionalization for immobilization. | |
| dc.language | en | |
| dc.rights | Atribución-NoComercial-SinDerivadas 3.0 Chile | |
| dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
| dc.source | Beilstein Journal of Organic Chemistry, 15, 1210-1216 | |
| dc.subject | Flow chemistry | |
| dc.subject | Heterogeneous catalysis | |
| dc.subject | Multicomponent reactions | |
| dc.subject | Organocatalysis | |
| dc.subject | Polyfurfuryl alcohol | |
| dc.title | Ugi reaction-derived prolyl peptide catalysts grafted on the renewable polymer polyfurfuryl alcohol for applications in heterogeneous enamine catalysis | |
| dc.type | Article | |
