Intoxicación por etilenglicol, fisiopatología y enfrentamiento clínico

Ethylene glycol poisoning. An update

dc.creatorSepúlveda, Rodrigo A.
dc.creatorSelamé, Esperanza
dc.creatorRoessler, Eric
dc.creatorTagle, Rodrigo
dc.creatorValdivieso, Andrés
dc.date2023-01-09T17:11:25Z
dc.date2023-01-09T17:11:25Z
dc.date2019
dc.date.accessioned2024-05-02T20:30:20Z
dc.date.available2024-05-02T20:30:20Z
dc.identifierhttp://repositorio.ucm.cl/handle/ucm/4352
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9274601
dc.descriptionToxic alcohols can produce severe poisoning with multiple organic involvement and even death. The most common form is ethylene glycol. The diagnosis can be extremely difficult if there is no history of its consumption. Its clinical presentation can simulate other conditions. Ethylene glycol poisoning is characterized by an initial rise in plasma osmolal gap that decreases during the evolution, while alcohol is metabolized to acids. This last condition causes a metabolic acidosis with elevated anion gap. The clinical manifestations are diffuse neurological involvement initially, followed by hemodynamic alterations due to myocardial damage associated with hypocalcemia and acidemia. Subsequently, severe tubular renal damage appears, which may require renal replacement therapy, and finally, focal neurological alterations. To treat this poisoning, it is necessary to inhibit the transformation of alcohol into acids, increase the metabolism of the latter or withdraw them directly with hemodialysis.
dc.languagees
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.sourceRevista Médica de Chile, 147(12), 1572-1578
dc.subjectAlcohols
dc.subjectEthylene glycol
dc.subjectPoisoning
dc.subjectTherapeutics
dc.titleIntoxicación por etilenglicol, fisiopatología y enfrentamiento clínico
dc.titleEthylene glycol poisoning. An update
dc.typeArticle


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