Rational design, synthesis and evaluation of γ-CD-containing cross-linked polyvinyl alcohol hydrogel as a prednisone delivery platform

dc.creatorMarican, Adolfo
dc.creatorAvila-Salas, Fabian
dc.creatorValdés, Oscar
dc.creatorWehinger, Sergio
dc.creatorVillaseñor, Jorge
dc.creatorFuentealba, Natalia
dc.creatorArenas-Salinas, Mauricio
dc.creatorArgandoña, Yerko
dc.creatorCarrasco-Sánchez, Verónica
dc.creatorDurán-Lara, Esteban F.
dc.date2022-12-29T17:43:39Z
dc.date2022-12-29T17:43:39Z
dc.date2018
dc.date.accessioned2024-05-02T20:30:11Z
dc.date.available2024-05-02T20:30:11Z
dc.identifierhttp://repositorio.ucm.cl/handle/ucm/4284
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9274532
dc.descriptionThis study describes the in-silico rational design, synthesis and evaluation of cross-linked polyvinyl alcohol hydrogels containing γ-cyclodextrin (γ-CDHSAs) as platforms for the sustained release of prednisone (PDN). Through in-silico studies using semi-empirical quantum mechanical calculations, the effectiveness of 20 dicarboxylic acids to generate a specific cross-linked hydrogel capable of supporting different amounts of γ-cyclodextrin (γ-CD) was evaluated. According to the interaction energies calculated with the in-silico studies, the hydrogel made from PVA cross-linked with succinic acids (SA) was shown to be the best candidate for containing γ-CD. Later, molecular dynamics simulation studies were performed in order to evaluate the intermolecular interactions between PDN and three cross-linked hydrogel formulations with different proportions of γ-CD (2.44%, 4.76% and 9.1%). These three cross-linked hydrogels were synthesized and characterized. The loading and the subsequent release of PDN from the hydrogels were investigated. The in-silico and experimental results showed that the interaction between PDN and γ-CDHSA was mainly produced with the γ-CDs linked to the hydrogels. Thus, the unique structures and properties of γ-CDHSA demonstrated an interesting multiphasic profile that could be utilized as a promising drug carrier for controlled, sustained and localized release of PDN.
dc.languageen
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.sourcePharmaceutics, 10(1), 30
dc.subjectDrug delivery
dc.subjectCrosslinking
dc.subjectPrednisone
dc.subjectCyclodextrins
dc.subjectSwelling
dc.subjectAccumulative release
dc.subjectThermogravimetric analysis
dc.titleRational design, synthesis and evaluation of γ-CD-containing cross-linked polyvinyl alcohol hydrogel as a prednisone delivery platform
dc.typeArticle


Este ítem pertenece a la siguiente institución