| dc.creator | Echeverría, Francisca | |
| dc.creator | Valenzuela, Rodrigo | |
| dc.creator | Bustamante, Andrés | |
| dc.creator | Álvarez, Daniela | |
| dc.creator | Ortiz, Macarena | |
| dc.creator | Soto-Alarcon, Sandra | |
| dc.creator | Muñoz, Patricio | |
| dc.creator | Corbari, Alicia | |
| dc.creator | Videla, Luis A. | |
| dc.date | 2022-12-26T13:03:02Z | |
| dc.date | 2022-12-26T13:03:02Z | |
| dc.date | 2018 | |
| dc.date.accessioned | 2024-05-02T20:30:07Z | |
| dc.date.available | 2024-05-02T20:30:07Z | |
| dc.identifier | http://repositorio.ucm.cl/handle/ucm/4258 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/9274511 | |
| dc.description | Pharmacological therapy for nonalcoholic fatty liver disease (NAFLD) is not approved at the present time. For this purpose, the effect of combined eicosapentaenoic acid (EPA; 50 mg/kg/day) modulating hepatic lipid metabolism and hydroxytyrosol (HT; 5 mg/kg/day) exerting antioxidant actions was evaluated on hepatic steatosis and oxidative stress induced by a high-fat diet (HFD; 60% fat, 20% protein, and 20% carbohydrates) compared to a control diet (CD; 10% fat, 20% protein, and 70% carbohydrates) in mice fed for 12 weeks. HFD-induced liver steatosis (i) was reduced by 32% by EPA, without changes in oxidative stress-related parameters and mild recovery of Nrf2 functioning affording antioxidation and (ii) was decreased by 42% by HT, concomitantly with total regain of the glutathione status diminished by HFD, 42% to 59% recovery of lipid peroxidation and protein oxidation enhanced by HFD, and regain of Nrf2 functioning, whereas (iii) combined EPA + HT supplementation elicited 74% reduction in liver steatosis, with total recovery of the antioxidant potential in a similar manner than HT. It is concluded that combined HT + EPA drastically decreases NAFLD development, an effect that shows additivity in HT and EPA effects that mainly relies on HT, strengthening the impact of oxidative stress as a central mechanism underlying liver steatosis in obesity. | |
| dc.language | en | |
| dc.rights | Atribución-NoComercial-SinDerivadas 3.0 Chile | |
| dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
| dc.source | Oxidative Medicine and Cellular Longevity, 2018, 5109503 | |
| dc.title | Attenuation of high-fat diet-induced rat liver oxidative stress and steatosis by combined hydroxytyrosol- (HT-) eicosapentaenoic acid supplementation mainly relies on HT | |
| dc.type | Article | |
