Synthesis and Antitumor Evaluation of Thiophene Analogs of Kigelinone

dc.creatorValderrama, Jaime A.
dc.creatorEspinoza, Omar
dc.creatorRodriguez, Jaime
dc.creatorTheoduloz, Cristina
dc.date.accessioned2024-01-10T12:43:17Z
dc.date.available2024-01-10T12:43:17Z
dc.date.created2024-01-10T12:43:17Z
dc.date.issued2009
dc.identifier10.2174/157017809788490006
dc.identifier1875-6255
dc.identifier1570-1786
dc.identifierhttps://doi.org/10.2174/157017809788490006
dc.identifierhttps://repositorio.uc.cl/handle/11534/77582
dc.identifierWOS:000267046600003
dc.description.abstractThe synthesis of kigelinone thiophene analogs and related naphtho[2,3-b] thiophene-4,9-quinones from 2-substituted 4,7-dimethoxybenzo[b]thiophenes via an oxidative deprotection, Diels-Alder, and oxidative aromatization reaction sequence is reported. The 2-substituted naphtho[2,3-b] thiophene-4,9-quinones display significant antitumor activity in the range IC50 1.1-47 mu M on a panel of four distinct human cancer cell lines.
dc.languageen
dc.publisherBENTHAM SCIENCE PUBL LTD
dc.rightsacceso restringido
dc.subjectQuinones
dc.subjectBenzo[b]thiophenes
dc.subjectOxidative deprotection
dc.subjectDiels-Alder reaction
dc.subjectRegioisomers
dc.subjectCitotoxicity
dc.subjectLEISHMANICIDAL ACTIVITY
dc.subjectANTIPROTOZOAL ACTIVITY
dc.subjectTABEBUIA-AVELLANEDAE
dc.subjectQUINONES
dc.subjectCYTOTOXICITY
dc.subjectFURANONAPHTHOQUINONES
dc.subjectHYDROQUINONES
dc.subjectRING
dc.titleSynthesis and Antitumor Evaluation of Thiophene Analogs of Kigelinone
dc.typeartículo


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