Regiochemical control in the amination reaction of phenanthridine-7,10-quinones

dc.creatorValderrama, Jaime A.
dc.creatorAndrea Ibacache, J.
dc.date.accessioned2024-01-10T12:42:00Z
dc.date.accessioned2024-05-02T20:10:47Z
dc.date.available2024-01-10T12:42:00Z
dc.date.available2024-05-02T20:10:47Z
dc.date.created2024-01-10T12:42:00Z
dc.date.issued2009
dc.identifier10.1016/j.tetlet.2009.05.042
dc.identifier0040-4039
dc.identifierhttps://doi.org/10.1016/j.tetlet.2009.05.042
dc.identifierhttps://repositorio.uc.cl/handle/11534/77471
dc.identifierWOS:000267495900016
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9273596
dc.description.abstractThe reaction of substituted phenanthridine-7,10-quinones with amines to construct novel aminophenanthridinequinone derivatives as antitumor agents is described. The regiochemistry of the amination reaction is discussed in terms of inductive and steric effects of remote substituents to the quinone ring, which Control the direction of the conjugate addition of the amines across the quinone double bond. Evidences on the significant in vitro antitumor activities of some of the obtained aminoquinones, are reported. (C) 2009 Elsevier Ltd. All rights Reserved.
dc.languageen
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.rightsacceso restringido
dc.subjectPhenanthridinequinones
dc.subjectSubstitution reaction
dc.subjectRegioselectivity
dc.subjectCytotoxicity
dc.titleRegiochemical control in the amination reaction of phenanthridine-7,10-quinones
dc.typeartículo


Este ítem pertenece a la siguiente institución