dc.creator | Germain, AM | |
dc.creator | Kato, S | |
dc.creator | Carvajal, JA | |
dc.creator | Valenzuela, GJ | |
dc.creator | Valdes, GL | |
dc.creator | Glasinovic, JC | |
dc.date.accessioned | 2024-01-10T13:11:27Z | |
dc.date.available | 2024-01-10T13:11:27Z | |
dc.date.created | 2024-01-10T13:11:27Z | |
dc.date.issued | 2003 | |
dc.identifier | 10.1067/S0002-9378(03)00545-3 | |
dc.identifier | 0002-9378 | |
dc.identifier | MEDLINE:14520238 | |
dc.identifier | https://doi.org/10.1067/S0002-9378(03)00545-3 | |
dc.identifier | https://repositorio.uc.cl/handle/11534/78048 | |
dc.identifier | WOS:000185219100060 | |
dc.description.abstract | OBJECTIVE: We tested the hypothesis that during intrahepatic cholestasis of pregnancy bile acids activate the myometrial oxytocin receptor pathway. | |
dc.description.abstract | STUDY DESIGN: Myometrial sensitivity to oxytocin and oxytocin-receptor messenger RNA and protein level was investigated. The ability of cholic acid to mediate such changes was evaluated. | |
dc.description.abstract | RESULTS: Cholestasis patients required lesser oxytocin to elicit four uterine contractions in 10 minutes (1.3 0.6 vs 3.6 0.8 J, P < .05, n = 7) and had lower in vitro ED50 (1.6 x 10-10 mol/L vs 1.0 x 10-8 mol/L, P < .05, n = 7) than controls. The 24-hour incubation of control myometrial strips (n = 7) with cholic acid (20 mmol/L) increased oxytocin sensitivity. Incubation of cultured myometrial cells (n = 5) with cholic acid increased oxytocin-receptor expression (messenger RNA and protein). | |
dc.description.abstract | CONCLUSION: We demonstrate that during intrahepatic cholestasis of pregnancy, an activation of the oxytocin receptor pathway occurs. This event seems to be the result of a cholic acid-mediated increase in oxytocin-receptor expression. | |
dc.language | en | |
dc.publisher | MOSBY, INC | |
dc.rights | acceso restringido | |
dc.subject | intrahepatic cholestasis of pregnancy | |
dc.subject | oxytocin receptor | |
dc.subject | INTRA-HEPATIC CHOLESTASIS | |
dc.subject | INTRAHEPATIC CHOLESTASIS | |
dc.subject | OBSTETRIC CHOLESTASIS | |
dc.subject | UTERINE ACTIVITY | |
dc.subject | PREGNANT-WOMEN | |
dc.subject | MESSENGER-RNA | |
dc.subject | CHOLIC-ACID | |
dc.subject | DECIDUA | |
dc.subject | PROTEIN | |
dc.subject | CELLS | |
dc.title | Bile acids increase response and expression of human myometrial oxytocin receptor | |
dc.type | artículo | |