Studies on quinones. Part 43: Synthesis and cytotoxic evaluation of polyoxyethylene-containing 1,4-naphthoquinones

dc.creatorValderrama, Jaime A.
dc.creatorLeiva, Hilda
dc.creatorRodriguez, Jaime A.
dc.creatorTheoduloz, Cristina
dc.creatorSchmeda Hirshmann, Guillermo
dc.date.accessioned2024-01-10T13:43:40Z
dc.date.accessioned2024-05-02T19:18:16Z
dc.date.available2024-01-10T13:43:40Z
dc.date.available2024-05-02T19:18:16Z
dc.date.created2024-01-10T13:43:40Z
dc.date.issued2008
dc.identifier10.1016/j.bmc.2008.02.018
dc.identifier1464-3391
dc.identifier0968-0896
dc.identifierMEDLINE:18299197
dc.identifierhttps://doi.org/10.1016/j.bmc.2008.02.018
dc.identifierhttps://repositorio.uc.cl/handle/11534/78716
dc.identifierWOS:000255245900022
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9272411
dc.description.abstractA series of naphthoquinones 2,3-disubstituted with chlorine and oxyethylene groups have been prepared from 2,3-dichloro- and 2,3-dimethoxy-1,4-naphthoquinone. The members of these series were tested on normal human. broblasts and on a panel of four human cancer cell lines. Antitumor activities, which were in the range of IC50 1.3-89.5 mu M, discussed in terms of LUMO energy, lipophilicity and size of the polyoxyethylene moiety. (C) 2008 Elsevier Ltd. All rights reserved.
dc.languageen
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.rightsacceso restringido
dc.subject1,4-naphthoquinones
dc.subjectpodands
dc.subjectcoronands
dc.subjectnucleophilic substitution
dc.subjectcytotoxicity
dc.subjectDNA TOPOISOMERASE-I
dc.subjectANTITUMOR-ACTIVITY
dc.subjectNAPHTHAZARIN DERIVATIVES
dc.subjectANTIPROLIFERATIVE ACTIVITY
dc.subjectLEISHMANICIDAL ACTIVITY
dc.subjectBIOLOGICAL-ACTIVITY
dc.subjectANTICANCER AGENTS
dc.subjectP-BENZOQUINONE
dc.subjectHYDROQUINONES
dc.subjectACCESS
dc.titleStudies on quinones. Part 43: Synthesis and cytotoxic evaluation of polyoxyethylene-containing 1,4-naphthoquinones
dc.typeartículo


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