dc.creator | Bridges, S. Louis, Jr. | |
dc.creator | Causey, Zenoria L. | |
dc.creator | Burgos, Paula I. | |
dc.creator | Huynh, B. Quynh N. | |
dc.creator | Hughes, Laura B. | |
dc.creator | Danila, Maria I. | |
dc.creator | van Everdingen, Amalia | |
dc.creator | Ledbetter, Stephanie | |
dc.creator | Conn, Doyt L. | |
dc.creator | Tamhane, Ashutosh | |
dc.creator | Westfall, Andrew O. | |
dc.creator | Jonas, Beth L. | |
dc.creator | Callahan, Leigh F. | |
dc.creator | Smith, Edwin A. | |
dc.creator | Brasington, Richard | |
dc.creator | Moreland, Larry W. | |
dc.creator | Alarcon, Graciela S. | |
dc.creator | van der Heijde, Desiree M. | |
dc.date.accessioned | 2024-01-10T12:07:56Z | |
dc.date.accessioned | 2024-05-02T18:36:45Z | |
dc.date.available | 2024-01-10T12:07:56Z | |
dc.date.available | 2024-05-02T18:36:45Z | |
dc.date.created | 2024-01-10T12:07:56Z | |
dc.date.issued | 2010 | |
dc.identifier | 10.1002/acr.20040 | |
dc.identifier | 2151-464X | |
dc.identifier | MEDLINE:20461784 | |
dc.identifier | https://doi.org/10.1002/acr.20040 | |
dc.identifier | https://repositorio.uc.cl/handle/11534/76339 | |
dc.identifier | WOS:000280979600007 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/9270734 | |
dc.description.abstract | Objective. To describe radiographic changes in African Americans with rheumatoid arthritis (RA) from the Consortium for the Longitudinal Evaluations of African Americans with Early Rheumatoid Arthritis (CLEAR) Registry, a multicenter observational study. | |
dc.description.abstract | Methods. Self-declared African American patients were enrolled in CLEAR I, a longitudinal cohort of early RA (disease duration of <2 years) from 2000 to 2005, or in CLEAR II, a cross-sectional cohort (any disease duration) from 2006 to the present. Demographic and clinical data were obtained, and sets of hand/wrist and foot radiographs were scored using the modified Sharp/van der Heijde scoring system. | |
dc.description.abstract | Results. A total of 357 and 418 patients were enrolled in CLEAR I and CLEAR II, respectively. We report here an interim analysis of radiographic severity in these patients. For the CLEAR I cohort, 294 patients had a mean radiographic score of 2.89 at the baseline visit; 32.0% showed either erosions (25.9%) or joint space narrowing (JSN; 19.4%). At the 36-month visit, the mean score was 5.65; 44.2% had erosions, 41.5% had JSN, and 54.4% had either. Among those patients without radiographic damage at baseline, 18.9% had progressed at the 36-month visit, compared with 57.1% of those with baseline damage (P < 0.0001). For the CLEAR II cohort, of 167 patients with RA of any duration, 65.3% exhibited joint erosions, 65.3% exhibited JSN, and 74.8% exhibited either. The mean radiographic score was 33.42. | |
dc.description.abstract | Conclusion. To our knowledge, this is the largest radiographic study of African American RA patients. Damage occurs early in the disease and is associated with radiographic progression at 3 years of disease duration. The CLEAR Registry will provide a valuable resource for future analyses of genetic, clinical, and environmental factors associated with radiographic severity of RA in African Americans. | |
dc.language | en | |
dc.publisher | WILEY-LISS | |
dc.rights | acceso restringido | |
dc.subject | PROSPECTIVE FOLLOW-UP | |
dc.subject | RADIOLOGICAL PROGRESSION | |
dc.subject | JOINT DESTRUCTION | |
dc.subject | NEGRO POPULATION | |
dc.subject | DISEASE-ACTIVITY | |
dc.subject | CLINICAL-TRIALS | |
dc.subject | MOTION SCALE | |
dc.subject | DAMAGE | |
dc.subject | BLACKS | |
dc.subject | ASSOCIATION | |
dc.title | Radiographic Severity of Rheumatoid Arthritis in African Americans: Results From a Multicenter Observational Study | |
dc.type | artículo | |