| dc.description.abstract | The pharmacokinetics of 2 doses of intravenous lysine clonixinate (4 and 6 mg x kg(-1)) were studied in 10 children (age 4 - 10 years) under postoperative care, A single dose of the drug was injected in a forearm vein, Blood samples were collected at regular intervals for 3 hours. Serum clonixin concentrations (expressed as clonixin) were analyzed using a high pressure liquid chromatography method, Pharmacokinetic values were estimated by a nonlinear computer program. The distribution volume was similar in both groups of children (1.288 +/- 0.829 1 and 1. 139 +/- 0.667 1, respectively). There were no differences between the values of total plasma clearance and the administered doses (0.026 +/- 0.017 ml x min(-1) and 0.017 +/- 0.008 ml x min(-1), t = 1.07, p = 0.76), The elimination half-life was longer in children who received 6 mg x kg(-1) (44.26 +/- 6.34 min vs 38.63 +/- 10.93 min) but this difference was not statistically significant (t = 0.99, p < 0.34). The pharmacokinetic parameters calculated in these children were different from those found by other authors in adults and experimental animals. | |
