artículo
Pancreatic neuroendocrine tumors. Surgical outcomes and overall survival
Fecha
2013Registro en:
10.4067/S0718-40262013000300006
0718-4026
WOS:000320483300006
Autor
Galindo R, Jose
Gabrielli N, Mauricio
Barros C, Diego
Moisan P, Fabrizio
Martinez M, Monica
Torres M, Javiera
Flores M, Macarena
Guerra C, Juan Francisco
Martinez C, Jorge
Jarufe C, Nicolas
Institución
Resumen
Background: Pancreatic neuroendocrine tumors (PNET) account for 1-2% of pancreatic neoplasms. Its incidence has increased in recent years probably due to improved imaging studies. Aim: To analyze the clinical characteristics, surgical outcomes and overall survival of patients with PNET who underwent resective surgery. Methods: Case series study. Data was collected from the central database and clinical records from patients with biopsy-proven PNET's who underwent surgical resection from June 2005 to June 2012. Results: Twenty patients were included (10.6% of all pancreatic resections), 12 female, with a median age of 44 [20-77] years. Abdominal pain was the most common symptom. Two patients had a type 1 multiple endocrine neoplasia (MEN-1) syndrome. Pre-operative work up included CT, MR and/or PET/CT. Five patients had functional tumors. Five Whipple procedures, 14 distal pancreatectomies and 1 enucleation were performed. Among the postoperative complications, there were 5 type B and 1 type C pancreatic fistulas. There was no mortality. At 31 [5-90] month median follow-up, overall survival was 100%. Conclusion: PNETs represent an increasing reason for pancreatic resection in our center. Surgical resection of the tumor with negative microscopic margins is the treatment of choice.