dc.creator | Romero, Roberto | |
dc.creator | Friel, Lara A. | |
dc.creator | Edwards, Digna R. Velez | |
dc.creator | Kusanovic, Juan Pedro | |
dc.creator | Hassan, Sonia S. | |
dc.creator | Mazaki Tovi, Shali | |
dc.creator | Vaisbuch, Edi | |
dc.creator | Kim, Chong Jai | |
dc.creator | Erez, Offer | |
dc.creator | Chaiworapongsa, Tinnakorn | |
dc.creator | Pearce, Brad D. | |
dc.creator | Bartlett, Jacquelaine | |
dc.creator | Salisbury, Benjamin A. | |
dc.creator | Anant, Madan Kumar | |
dc.creator | Vovis, Gerald F. | |
dc.creator | Lee, Min Seob | |
dc.creator | Gomez, Ricardo | |
dc.creator | Behnke, Ernesto | |
dc.creator | Oyarzun, Enrique | |
dc.creator | Tromp, Gerard | |
dc.creator | Williams, Scott M. | |
dc.creator | Menon, Ramkumar | |
dc.date.accessioned | 2024-01-10T12:37:27Z | |
dc.date.accessioned | 2024-05-02T16:48:34Z | |
dc.date.available | 2024-01-10T12:37:27Z | |
dc.date.available | 2024-05-02T16:48:34Z | |
dc.date.created | 2024-01-10T12:37:27Z | |
dc.date.issued | 2010 | |
dc.identifier | 10.1016/j.ajog.2010.05.026 | |
dc.identifier | 1097-6868 | |
dc.identifier | 0002-9378 | |
dc.identifier | MEDLINE:20673868 | |
dc.identifier | https://doi.org/10.1016/j.ajog.2010.05.026 | |
dc.identifier | https://repositorio.uc.cl/handle/11534/76852 | |
dc.identifier | WOS:000282287000034 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/9267121 | |
dc.description.abstract | OBJECTIVE: We sought to determine whether maternal/fetal single-nucleotide polymorphisms (SNPs) in candidate genes are associated with preterm prelabor rupture of membranes (pPROM). | |
dc.description.abstract | STUDY DESIGN: A case-control study was conducted in patients with pPROM (225 mothers and 155 fetuses) and 599 mothers and 628 fetuses with a normal pregnancy; 190 candidate genes and 775 SNPs were studied. Single locus/haplotype association analyses were performed; false discovery rate was used to correct for multiple testing (q(star) = 0.15). | |
dc.description.abstract | RESULTS: First, a SNP in tissue inhibitor of metalloproteinase 2 in mothers was significantly associated with pPROM (odds ratio, 2.12; 95% confidence interval, 1.47-3.07; P = .000068), and this association remained significant after correction for multiple comparisons. Second, haplotypes for Alpha 3 type IV collagen isoform precursor in the mother were associated with pPROM ( global P = .003). Third, multilocus analysis identified a 3-locus model, which included maternal SNPs in collagen type I alpha 2, defensin alpha 5 gene, and endothelin 1. | |
dc.description.abstract | CONCLUSION: DNA variants in a maternal gene involved in extracellular matrix metabolism doubled the risk of pPROM. | |
dc.language | en | |
dc.publisher | MOSBY-ELSEVIER | |
dc.rights | acceso restringido | |
dc.subject | chorioamnionitis | |
dc.subject | DNA variants | |
dc.subject | extracellular matrix | |
dc.subject | genetic association study | |
dc.subject | genomics | |
dc.subject | genotype | |
dc.subject | haplotype | |
dc.subject | high dimensional biology | |
dc.subject | matrix metalloproteinase | |
dc.subject | parturition | |
dc.subject | prematurity | |
dc.subject | preterm prelabor rupture of membranes | |
dc.subject | single-nucleotide polymorphism | |
dc.subject | TUMOR-NECROSIS-FACTOR | |
dc.subject | INTERLEUKIN-1 RECEPTOR ANTAGONIST | |
dc.subject | MIDTRIMESTER AMNIOTIC-FLUID | |
dc.subject | FACTOR-ALPHA GENE | |
dc.subject | SINGLE NUCLEOTIDE POLYMORPHISM | |
dc.subject | EHLERS-DANLOS-SYNDROME | |
dc.subject | FALSE DISCOVERY RATE | |
dc.subject | HUMAN UTERINE CERVIX | |
dc.subject | THAN-G POLYMORPHISM | |
dc.subject | PREMATURE-RUPTURE | |
dc.title | A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM) | |
dc.type | artículo | |