A STUDY ON THE ANTIGENIC NATURE OF CIRCULATING IMMUNE-COMPLEXES IN HEMOLYTIC-UREMIC SYNDROME - NO EVIDENCE OF PLATELET MEMBRANE GLYCOPROTEIN ANTIGENS

dc.creatorOLAVARRIA, F
dc.creatorPEREIRA, J
dc.creatorMEZZANO, S
dc.creatorKUNICK, M
dc.creatorCASTILLO, A
dc.date.accessioned2024-01-10T12:37:43Z
dc.date.available2024-01-10T12:37:43Z
dc.date.created2024-01-10T12:37:43Z
dc.date.issued1994
dc.identifier10.1159/000187766
dc.identifier0028-2766
dc.identifierMEDLINE:8107954
dc.identifierhttps://doi.org/10.1159/000187766
dc.identifierhttps://repositorio.uc.cl/handle/11534/76908
dc.identifierWOS:A1994MM87300009
dc.description.abstractCirculating immune complexes (CIC) have been described in the hemolytic uremic syndrome (HUS) in children. They may represent an epiphenomenon or could be related to the platelet activation and endothelial damage observed in this disease. In an attempt to define this relationship, we investigated the CIC isolated in 17 patients with the classic form of HUS, by means of monoclonal antibodies against platelet surface glycoprotein Ib and IIb-IIIa complex. The negative results obtained do not support the possibility of platelet antigens being constituents of CIC and make an antibody-induced platelet activation in HUS very unlikely.
dc.languageen
dc.publisherKARGER
dc.rightsacceso restringido
dc.subjectHEMOLYTIC UREMIC SYNDROME
dc.subjectCIRCULATING IMMUNE COMPLEXES
dc.subjectPLATELET MEMBRANE GLYCOPROTEIN
dc.subjectTHROMBOCYTOPENIC PURPURA
dc.subjectIIIA
dc.titleA STUDY ON THE ANTIGENIC NATURE OF CIRCULATING IMMUNE-COMPLEXES IN HEMOLYTIC-UREMIC SYNDROME - NO EVIDENCE OF PLATELET MEMBRANE GLYCOPROTEIN ANTIGENS
dc.typeartículo


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