dc.creator | INESTROSA, NC | |
dc.creator | ALARCON, R | |
dc.creator | ARRIAGADA, J | |
dc.creator | DONOSO, A | |
dc.creator | ALVAREZ, J | |
dc.creator | CAMPOS, EO | |
dc.date.accessioned | 2024-01-10T12:37:50Z | |
dc.date.accessioned | 2024-05-02T16:38:51Z | |
dc.date.available | 2024-01-10T12:37:50Z | |
dc.date.available | 2024-05-02T16:38:51Z | |
dc.date.created | 2024-01-10T12:37:50Z | |
dc.date.issued | 1994 | |
dc.identifier | 10.1016/0022-510X(94)90044-2 | |
dc.identifier | 0022-510X | |
dc.identifier | MEDLINE:8195795 | |
dc.identifier | https://doi.org/10.1016/0022-510X(94)90044-2 | |
dc.identifier | https://repositorio.uc.cl/handle/11534/76934 | |
dc.identifier | WOS:A1994MZ29400001 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/9266716 | |
dc.description.abstract | In patients with the clinical diagnosis of Alzheimer disease (AD), we searched for systemic changes in components of the blood as a diagnostic tool. The acetylcholine-related enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) were measured in plasma, erythrocytes, platelets and lymphocytes. Results did not show a general effect; notwithstanding, specific cell types presented alterations either in AChE or BuChE but not in both enzymatic activities. In AD patients, AChE of lymphocytes was reduced by 60% compared with the age-matched controls. However, when patients were divided, the sporadic but not the familial subgroup exhibited a significant reduction. In erythrocytes the BuChE activity was reduced by 45% in sporadic AD. The molecular forms of the lymphocyte AChE were characterized by velocity sedimentation. Both globular forms were subnormal, more so the tetrameric G(4) AChE form than the G(2) form. | |
dc.language | en | |
dc.publisher | ELSEVIER SCIENCE BV | |
dc.rights | acceso restringido | |
dc.subject | CHOLINERGIC MARKERS | |
dc.subject | LYMPHOCYTES | |
dc.subject | ERYTHROCYTES | |
dc.subject | PLATELETS | |
dc.subject | PLASMA | |
dc.subject | ALZHEIMERS DISEASE | |
dc.subject | DIAGNOSTIC TEST | |
dc.subject | SENILE DEMENTIA | |
dc.subject | MOLECULAR-FORMS | |
dc.subject | PRECURSOR | |
dc.subject | DIAGNOSIS | |
dc.subject | PROTEIN | |
dc.subject | PLASMA | |
dc.title | BLOOD MARKERS IN ALZHEIMER-DISEASE - SUBNORMAL ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE IN LYMPHOCYTES AND ERYTHROCYTES | |
dc.type | artículo | |