The 3 ' Untranslated Region of the Andes Hantavirus Small mRNA Functionally Replaces the Poly(A) Tail and Stimulates Cap-Dependent Translation Initiation from the Viral mRNA

dc.creatorVera Otarola, Jorge
dc.creatorSoto Rifo, Ricardo
dc.creatorRicci, Emiliano P.
dc.creatorOhlmann, Theophile
dc.creatorDarlix, Jean Luc
dc.creatorLopez Lastra, Marcelo
dc.date.accessioned2024-01-10T12:09:16Z
dc.date.available2024-01-10T12:09:16Z
dc.date.created2024-01-10T12:09:16Z
dc.date.issued2010
dc.identifier10.1128/JVI.01270-10
dc.identifier1098-5514
dc.identifier0022-538X
dc.identifierMEDLINE:20660206
dc.identifierhttps://doi.org/10.1128/JVI.01270-10
dc.identifierhttps://repositorio.uc.cl/handle/11534/76474
dc.identifierWOS:000282641800073
dc.description.abstractIn the process of translation of eukaryotic mRNAs, the 5' cap and the 3' poly(A) tail interact synergistically to stimulate protein synthesis. Unlike its cellular counterparts, the small mRNA (SmRNA) of Andes hantavirus (ANDV), a member of the Bunyaviridae, lacks a 3' poly(A) tail. Here we report that the 3' untranslated region (3'UTR) of the ANDV SmRNA functionally replaces a poly(A) tail and synergistically stimulates cap-dependent translation initiation from the viral mRNA. Stimulation of translation by the 3'UTR of the ANDV SmRNA was found to be independent of viral proteins and of host poly(A)-binding protein.
dc.languageen
dc.publisherAMER SOC MICROBIOLOGY
dc.rightsacceso restringido
dc.subjectPOLY(A)-BINDING PROTEIN
dc.subjectINDEPENDENT TRANSLATION
dc.subjectPROTEOLYTIC CLEAVAGE
dc.subjectNUCLEOCAPSID PROTEIN
dc.subjectVIRUS
dc.subjectBINDING
dc.subjectEIF4GI
dc.subjectCELLS
dc.subjectIDENTIFICATION
dc.subjectREPLICATION
dc.titleThe 3 ' Untranslated Region of the Andes Hantavirus Small mRNA Functionally Replaces the Poly(A) Tail and Stimulates Cap-Dependent Translation Initiation from the Viral mRNA
dc.typeartículo


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