dc.creatorSoto, GD
dc.creatorLopez Kostner, F
dc.creatorZarate, AC
dc.creatorVuletin, FS
dc.creatorRahmer, AO
dc.creatorLeon, FG
dc.creatorZuniga, AD
dc.date.accessioned2024-01-10T12:10:22Z
dc.date.available2024-01-10T12:10:22Z
dc.date.created2024-01-10T12:10:22Z
dc.date.issued2005
dc.identifier0717-6163
dc.identifier0034-9887
dc.identifierMEDLINE:16311696
dc.identifierhttps://repositorio.uc.cl/handle/11534/76571
dc.identifierWOS:000233207100007
dc.description.abstractBackground: To reduce the mortality associated to Familial Adenomatous Polyposis (FAP), screening of close relatives of patients with the disease is crucial. Aim To analyze the result of the surgical treatment of patients with FAP and to evaluate the family screening Patients and Methods. Clinical records of patients operated in our institution since 1977, were reviewed analyzing surgical and pathological results, and follow up. In their family members, we evaluated and analyzed the performance of screening tests, former surgeries, history of disease-related cancer and mortality, all due to FAP Results: Between January 1977 and August 2002, 15 patients were operated on. Of these, only 33% consulted on the setting of a familial screening. A proctocolectomy and terminal ileostomy was performed in 27% of patients; 20% had a proctocolectomy and ileal pouch, and 53% underwent a total colectomy with ileo-rectal anastomosis. Morbidity and mortality were 7% and 0%, respectively. Twenty percent bad a colorectal cancer. During a median of 68 months follow-up, the disease-related survivial was 92%; no cancer of the rectal stump was detected. of the 122 family members identified, only 33% with clear indication of screening underwent a colonoscopy. Twenty-nine percent bad a confirmed FAP and were operated: in 61% of them a colorectal cancer was found, and 9.1% of these died. Conclusions: The results of the surgical treatment of FAP are satisfactory. Nevertheless, family screening should be improved to reduce the high rates of mortality revealed it? the study of other family members.
dc.languagees
dc.publisherSOC MEDICA SANTIAGO
dc.rightsregistro bibliográfico
dc.subjectadenomatous polyposis coli
dc.subjectcolorectal neoplasms
dc.subjectfamilial adenomatous polyposis
dc.subjectPOUCH-ANAL ANASTOMOSIS
dc.subjectNONPOLYPOSIS COLORECTAL-CANCER
dc.subjectILEAL POUCH
dc.subjectILEORECTAL ANASTOMOSIS
dc.subjectPROCTOCOLECTOMY
dc.subjectMANAGEMENT
dc.subjectCOLECTOMY
dc.subjectCHOICE
dc.titleTreatment of familial adenomatous polyposis and family screening
dc.typeartículo


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