Computational aspects of nonparametric Bayesian analysis with applications to the modeling of multiple binary sequences

Abstract

We consider Markov mixture models for multiple longitudinal binary sequences. Prior uncertainty in the mixing distribution is characterized by a Dirichlet process centered on a matrix beta measure. We use this setting to evaluate and compare the performance of three competing algorithms that arise more generally in Dirichlet process mixture calculations: sequential imputations, Gibbs sampling, and a predictive recursion, for which an extension of the sequential calculations is introduced. This facilitates the estimation of quantities related to clustering structure which is not available in the original formulation. A numerical comparison is carried out in three examples. Our findings suggest that the sequential imputations method is most useful for relatively small problems, and that the predictive recursion can be an efficient preliminary tool for more reliable, but computationally intensive, Gibbs sampling implementations.