Solvent-free microwave synthesis of 3-(4-benzo[b]thiophene-2-carbonyl)-1-piperazinyl-1-benzo[b]thiophen-2-yl-1-propanones. New hetero bis-ligands with potential 5-HT1A serotonergic activity

dc.creatorPessoa Mahana, Hernan
dc.creatorKosche, Johann
dc.creatorRon, Nadia
dc.creatorRecabarren Gajardo, Gonzalo
dc.creatorSaitz, Claudio
dc.creatorAraya Maturana, Rarniro
dc.creatorPessoa Mahana, David
dc.date.accessioned2024-01-10T14:21:42Z
dc.date.accessioned2024-05-02T16:02:01Z
dc.date.available2024-01-10T14:21:42Z
dc.date.available2024-05-02T16:02:01Z
dc.date.created2024-01-10T14:21:42Z
dc.date.issued2008
dc.identifier10.3987/COM-08-11326
dc.identifier1881-0942
dc.identifier0385-5414
dc.identifierhttps://doi.org/10.3987/COM-08-11326
dc.identifierhttps://repositorio.uc.cl/handle/11534/79755
dc.identifierWOS:000259131300003
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9265696
dc.description.abstractA novel series of 2-benzothiophenealkylpiperazine derivatives 11 (a-d) with potential affinity at 5-HT1A serotonin receptors have been synthesized via solvent-free, microwave-promoted Michael addition of benzo[b]thiophene piperazine derivatives 6(a-c) to substituted benzo[b]thiophen-2-yl propenones 10(b,c).
dc.languageen
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.rightsregistro bibliográfico
dc.subjectdepression
dc.subjectMichael addition
dc.subjectserotonin
dc.subjectbenzothiophene
dc.subjectarylpiperazine
dc.subjectMICHAEL ADDITION
dc.subjectRECEPTOR
dc.subjectDERIVATIVES
dc.subjectQUINONES
dc.subject4-ARYLPIPERAZINES
dc.subjectIRRADIATION
dc.titleSolvent-free microwave synthesis of 3-(4-benzo[b]thiophene-2-carbonyl)-1-piperazinyl-1-benzo[b]thiophen-2-yl-1-propanones. New hetero bis-ligands with potential 5-HT1A serotonergic activity
dc.typeartículo


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