The Incubation of 13α,17-Dihydroxystemodane with Cephalosporium aphidicola

dc.creatorFraga, B.
dc.creatorGuillermo, R.
dc.creatorHernández, M.
dc.creatorChamy, M.
dc.creatorGarbarino, J.
dc.date.accessioned2023-07-12T13:44:32Z
dc.date.accessioned2024-05-02T15:14:14Z
dc.date.available2023-07-12T13:44:32Z
dc.date.available2024-05-02T15:14:14Z
dc.date.created2023-07-12T13:44:32Z
dc.date.issued2012-02
dc.identifierMolecules, Volume 17, Issue 2, Pages 1744 - 1750, February 2012
dc.identifier1420-3049
dc.identifierhttps://repositorio.unab.cl/xmlui/handle/ria/51595
dc.identifier10.3390/molecules17021744
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9264127
dc.description.abstractThe biotransformation of 13α,17-dihydroxystemodane (3) with the fungus Cephalosporium aphidicola afforded 13α,17,18-trihydroxystemodane (4), 3β,13α,17-trihydroxystemodane (5), 13α,17-dihydroxy- stemodan-18-oic acid (6), 3β,11β,13α,17-tetrahydroxystemodane (7), 11β,13α,17,18-tetrahydroxystemodane (8) and 3β,13α, 17,18-tetrahydroxystemodane (9). The hydroxylation at C-18 of the substrate points to a biosynthetically-directed transformation, because aphidicolin (2) is hydroxylated at this carbon. However, the C-3(β) and C-11(β) hydroxylations seem to indicate a xenobiotic biotransformation.
dc.languageen
dc.publisherMDPI AG
dc.rightshttps://www.mdpi.com/openaccess
dc.rightsAttribution 4.0 International (CC BY 4.0)
dc.subjectBiotransformations
dc.subjectCephalosporium aphidicola
dc.subjectDiterpenes
dc.subjectStemodane
dc.titleThe Incubation of 13α,17-Dihydroxystemodane with Cephalosporium aphidicola
dc.typeArtículo


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