A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection

dc.creatorCruces, Pablo
dc.creatorRetamal, Jaime
dc.creatorHurtado, Daniel E.
dc.creatorErranz, Benjamín
dc.creatorIturrieta, Pablo
dc.creatorGonzález, Carlos
dc.creatorDíaz, Franco
dc.date.accessioned2022-06-15T17:12:02Z
dc.date.accessioned2024-05-02T15:07:25Z
dc.date.available2022-06-15T17:12:02Z
dc.date.available2024-05-02T15:07:25Z
dc.date.created2022-06-15T17:12:02Z
dc.date.issued2020-08
dc.identifierCritical Care Open Access Volume 24, Issue 110 August 2020 Article number 494
dc.identifier13648535
dc.identifierhttps://repositorio.unab.cl/xmlui/handle/ria/22846
dc.identifier10.1186/s13054-020-03197-7
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9262836
dc.description.abstractDeterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it. Given the limited understanding of P-SILI, we describe the physiological basis of P-SILI and we show experimental data to comprehend the role of regional strain and heterogeneity in lung injury due to increased work of breathing. In addition, we discuss the current approach to respiratory support for COVID-19 under this point of view. © 2020 The Author(s).
dc.languageen
dc.publisherBioMed Central Ltd
dc.rightshttps://creativecommons.org/licenses/by/4.0/
dc.rightsAttribution 4.0 International (CC BY 4.0)
dc.subjectCOVID-19
dc.subjectLung strain
dc.subjectMechanical ventilation
dc.subjectP-SILI
dc.subjectSARS-CoV2
dc.subjectWork of breathing
dc.titleA physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection
dc.typeArtículo


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