Study on the cytotoxic activity of drimane sesquiterpenes and nordrimane compounds against cancer cell lines
dc.creator | Montenegro, Ivan | |
dc.creator | Tomasoni, Giacomo | |
dc.creator | Bosio, Claudia | |
dc.creator | Quiñones, Natalia | |
dc.creator | Madrid, Alejandro | |
dc.creator | Carrasco, Hector | |
dc.creator | Olea, Andres | |
dc.creator | Martinez, Rolando | |
dc.creator | Cuellar, Mauricio | |
dc.creator | Villena, Joan | |
dc.date.accessioned | 2023-01-03T18:35:55Z | |
dc.date.accessioned | 2024-05-02T15:06:23Z | |
dc.date.available | 2023-01-03T18:35:55Z | |
dc.date.available | 2024-05-02T15:06:23Z | |
dc.date.created | 2023-01-03T18:35:55Z | |
dc.date.issued | 2014 | |
dc.identifier | 1420-3049 | |
dc.identifier | https://repositorio.unab.cl/xmlui/handle/ria/35776 | |
dc.identifier | 10.3390/molecules191118993 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/9262516 | |
dc.description.abstract | Twelve drimanes, including polygodial (1), isopolygodial (2), drimenol (3), confertifolin (4), and isodrimenin (5), were obtained from natural sources. Semi-synthetic derivatives 6-12 were obtained from 1 and 2, and cytotoxic activity was evaluated in vitro against cancer cell lines (HT-29, MDA-MB231, DHF, MCF-7, PC-3, DU-145, and CoN). IC50 values were determined at concentrations of 12.5-100 ìM of each compound for 72 h. In addition, it was found that polygodial (1), 8, and 12 induced changes in mitochondrial membrane permeability in CoN, MCF-7, and PC-3 cells. © 2014 by the authors. | |
dc.language | en | |
dc.publisher | MDPI AG | |
dc.rights | https://creativecommons.org/licenses/by/4.0/deed.es | |
dc.rights | Atribución 4.0 Internacional (CC BY 4.0) | |
dc.subject | Apoptosis | |
dc.subject | Cancer cell lines | |
dc.subject | Caspasa-3 activity | |
dc.subject | Cytotoxic activity | |
dc.subject | Drimanes | |
dc.subject | Mitochondrial membrane permeability | |
dc.subject | Nordrimanes | |
dc.subject | Sesquiterpenes | |
dc.title | Study on the cytotoxic activity of drimane sesquiterpenes and nordrimane compounds against cancer cell lines | |
dc.type | Artículo |