dc.creatorMontenegro, Ivan
dc.creatorTomasoni, Giacomo
dc.creatorBosio, Claudia
dc.creatorQuiñones, Natalia
dc.creatorMadrid, Alejandro
dc.creatorCarrasco, Hector
dc.creatorOlea, Andres
dc.creatorMartinez, Rolando
dc.creatorCuellar, Mauricio
dc.creatorVillena, Joan
dc.date.accessioned2023-01-03T18:35:55Z
dc.date.accessioned2024-05-02T15:06:23Z
dc.date.available2023-01-03T18:35:55Z
dc.date.available2024-05-02T15:06:23Z
dc.date.created2023-01-03T18:35:55Z
dc.date.issued2014
dc.identifier1420-3049
dc.identifierhttps://repositorio.unab.cl/xmlui/handle/ria/35776
dc.identifier10.3390/molecules191118993
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9262516
dc.description.abstractTwelve drimanes, including polygodial (1), isopolygodial (2), drimenol (3), confertifolin (4), and isodrimenin (5), were obtained from natural sources. Semi-synthetic derivatives 6-12 were obtained from 1 and 2, and cytotoxic activity was evaluated in vitro against cancer cell lines (HT-29, MDA-MB231, DHF, MCF-7, PC-3, DU-145, and CoN). IC50 values were determined at concentrations of 12.5-100 ìM of each compound for 72 h. In addition, it was found that polygodial (1), 8, and 12 induced changes in mitochondrial membrane permeability in CoN, MCF-7, and PC-3 cells. © 2014 by the authors.
dc.languageen
dc.publisherMDPI AG
dc.rightshttps://creativecommons.org/licenses/by/4.0/deed.es
dc.rightsAtribución 4.0 Internacional (CC BY 4.0)
dc.subjectApoptosis
dc.subjectCancer cell lines
dc.subjectCaspasa-3 activity
dc.subjectCytotoxic activity
dc.subjectDrimanes
dc.subjectMitochondrial membrane permeability
dc.subjectNordrimanes
dc.subjectSesquiterpenes
dc.titleStudy on the cytotoxic activity of drimane sesquiterpenes and nordrimane compounds against cancer cell lines
dc.typeArtículo


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