Study on the cytotoxic activity of drimane sesquiterpenes and nordrimane compounds against cancer cell lines

dc.creatorMontenegro, Ivan
dc.creatorTomasoni, Giacomo
dc.creatorBosio, Claudia
dc.creatorQuiñones, Natalia
dc.creatorMadrid, Alejandro
dc.creatorCarrasco, Hector
dc.creatorOlea, Andres
dc.creatorMartinez, Rolando
dc.creatorCuellar, Mauricio
dc.creatorVillena, Joan
dc.date.accessioned2023-01-03T18:35:55Z
dc.date.accessioned2024-05-02T15:06:23Z
dc.date.available2023-01-03T18:35:55Z
dc.date.available2024-05-02T15:06:23Z
dc.date.created2023-01-03T18:35:55Z
dc.date.issued2014
dc.identifier1420-3049
dc.identifierhttps://repositorio.unab.cl/xmlui/handle/ria/35776
dc.identifier10.3390/molecules191118993
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9262516
dc.description.abstractTwelve drimanes, including polygodial (1), isopolygodial (2), drimenol (3), confertifolin (4), and isodrimenin (5), were obtained from natural sources. Semi-synthetic derivatives 6-12 were obtained from 1 and 2, and cytotoxic activity was evaluated in vitro against cancer cell lines (HT-29, MDA-MB231, DHF, MCF-7, PC-3, DU-145, and CoN). IC50 values were determined at concentrations of 12.5-100 ìM of each compound for 72 h. In addition, it was found that polygodial (1), 8, and 12 induced changes in mitochondrial membrane permeability in CoN, MCF-7, and PC-3 cells. © 2014 by the authors.
dc.languageen
dc.publisherMDPI AG
dc.rightshttps://creativecommons.org/licenses/by/4.0/deed.es
dc.rightsAtribución 4.0 Internacional (CC BY 4.0)
dc.subjectApoptosis
dc.subjectCancer cell lines
dc.subjectCaspasa-3 activity
dc.subjectCytotoxic activity
dc.subjectDrimanes
dc.subjectMitochondrial membrane permeability
dc.subjectNordrimanes
dc.subjectSesquiterpenes
dc.titleStudy on the cytotoxic activity of drimane sesquiterpenes and nordrimane compounds against cancer cell lines
dc.typeArtículo


Este ítem pertenece a la siguiente institución