dc.creatorYameen, Basit
dc.creatorChoi, Won Il
dc.creatorVilos, Cristian
dc.creatorSwami, Archana
dc.creatorShi, Jinjun
dc.creatorFarokhzad, Omid C.
dc.date.accessioned2023-01-10T15:17:59Z
dc.date.accessioned2024-05-02T15:00:52Z
dc.date.available2023-01-10T15:17:59Z
dc.date.available2024-05-02T15:00:52Z
dc.date.created2023-01-10T15:17:59Z
dc.date.issued2014
dc.identifier0168-3659
dc.identifierhttps://repositorio.unab.cl/xmlui/handle/ria/35943
dc.identifier10.1016/j.jconrel.2014.06.038
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9261125
dc.description.abstractCollaborative efforts from the fields of biology, materials science, and engineering are leading to exciting progress in the development of nanomedicines. Since the targets of many therapeutic agents are localized in subcellular compartments, modulation of nanoparticle-cell interactions for efficient cellular uptake through the plasma membrane and the development of nanomedicines for precise delivery to subcellular compartments remain formidable challenges. Cellular internalization routes determine the post-internalization fate and intracellular localization of nanoparticles. This review highlights the cellular uptake routes most relevant to the field of non-targeted nanomedicine and presents an account of ligand-targeted nanoparticles for receptor-mediated cellular internalization as a strategy for modulating the cellular uptake of nanoparticles. Ligand-targeted nanoparticles have been the main impetus behind the progress of nanomedicines towards the clinic. This strategy has already resulted in remarkable progress towards effective oral delivery of nanomedicines that can overcome the intestinal epithelial barrier. A detailed overview of the recent developments in subcellular targeting as a novel platform for next-generation organelle-specific nanomedicines is also provided. Each section of the review includes prospects, potential, and concrete expectations from the field of targeted nanomedicines and strategies to meet those expectations. © 2014 Elsevier B.V. All rights reserved.
dc.languageen
dc.rightshttps://creativecommons.org/licenses/by/4.0/deed.es
dc.rightsAtribución 4.0 Internacional (CC BY 4.0)
dc.subjectIntracellular distribution
dc.subjectNanomedicine
dc.subjectNanoparticle cellular uptake
dc.subjectNon-targeted and targeted nanoparticles
dc.subjectsubcellular targeting
dc.titleInsight into nanoparticle cellular uptake and intracellular targeting
dc.typeArtículo


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