Coprocessing of cellulose II with amorphous silicon dioxide: effect of silicification on the powder and tableting properties

dc.creatorRojas Camargo, John
dc.creatorKumar, Vijay
dc.date2023-06-09T14:06:32Z
dc.date2023-06-09T14:06:32Z
dc.date2012
dc.date.accessioned2024-04-23T18:17:13Z
dc.date.available2024-04-23T18:17:13Z
dc.identifierRojas J, Kumar V. Coprocessing of cellulose II with amorphous silicon dioxide: effect of silicification on the powder and tableting properties. Drug Dev Ind Pharm. 2012 Feb;38(2):209-26. doi: 10.3109/03639045.2011.597400.
dc.identifier0363-9045
dc.identifierhttps://hdl.handle.net/10495/35421
dc.identifier10.3109/03639045.2011.597400
dc.identifier1520-5762
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9230624
dc.descriptionABSTRACT: Aim: In recent years, coprocessing has been the most successful approach to improve and correct the functionality of excipients. The aim of this study is to coprocessed cellulose II with SiO(2) and to evaluate the resulting powder and tableting properties. Methods: Novel cellulose II:SiO(2) (98:2, 95:5, 90:10 and 80:20 w/w ratios) composites were produced by spray drying, wet granulation and spheronization techniques and the resulting powder and tableting properties were assessed. Results: Cellulose II:SiO(2) composites produced by spray- drying exhibited spherical/oblongate shape, narrow distribution and mean diameter from 51 to 75 µm. The composites produced by wet granulation had larger distribution, granular shape and a mean diameter from 105 to 129 µm. The spheronized composites showed the highest size (from 148 to 450 µm) and round shape. Bulk and tap densities and flow were reduced as the silicification level increased in the spray dried and wet granulated materials. Likewise, silicification increased the true density, porosity and surface roughness of these materials. Water sorption decreased only at silicification level of 20% being comparable to the ones shown by Prosolv(®) samples. Contact angles of all cellulose II materials were lower than those of cellulose I except for Celphere203 indicating better wettability. A 5% and 10% silicification levels rendered the strongest compacts for the spray dried and wet granulated materials, respectively. Silicification did not affect the fast disintegration properties of MCCII. Conclusions: Coprocessing proved to be useful tool to modify the powder and tableting properties of cellulose II.
dc.descriptionCOL0003623
dc.format19
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherTaylor and Francis
dc.publisherDiseño y Formulación de Medicamentos Cosméticos y Afines
dc.publisherLondres, Inglaterra
dc.relationDrug Dev. Ind. Pharm.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectCelulosa - Química
dc.subjectCellulose - Chemistry
dc.subjectComposición de Medicamentos - métodos
dc.subjectDrug Compounding - methods
dc.subjectExcipientes - Química
dc.subjectExcipients - Chemistry
dc.subjectTamaño de la Partícula
dc.subjectParticle Size
dc.subjectPolvos - Química
dc.subjectPowders - Chemistry
dc.subjectDióxido de Silicio - Química
dc.subjectSilicon Dioxide - Chemistry
dc.subjectComprimidos - Química
dc.subjectTablets - Chemistry
dc.titleCoprocessing of cellulose II with amorphous silicon dioxide: effect of silicification on the powder and tableting properties
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typehttp://purl.org/coar/resource_type/c_2df8fbb1
dc.typehttps://purl.org/redcol/resource_type/ART
dc.typeArtículo de investigación


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