Chitosan-Acrylic Polymeric Nanoparticles with Dynamic Covalent Bonds. Synthesis and Stimuli Behavior

dc.creatorPalacio Torres, Hermán Darío
dc.creatorOtálvaro Tamayo, Felipe
dc.creatorGiraldo Morales, Luis Fernando
dc.creatorPonchel, Gilles
dc.creatorSegura Sánchez, Freimar
dc.date2023-06-08T19:58:08Z
dc.date2023-06-08T19:58:08Z
dc.date2017
dc.date.accessioned2024-04-23T17:42:02Z
dc.date.available2024-04-23T17:42:02Z
dc.identifierPalacio H, Otálvaro F, Giraldo LF, Ponchel G, Segura-Sánchez F. Chitosan-Acrylic Polymeric Nanoparticles with Dynamic Covalent Bonds. Synthesis and Stimuli Behavior. Chem Pharm Bull (Tokyo). 2017 Dec 1;65(12):1132-1143. doi: 10.1248/cpb.c17-00624.
dc.identifier0009-2363
dc.identifierhttps://hdl.handle.net/10495/35388
dc.identifier10.1248/cpb.c17-00624
dc.identifier1347-5223
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9229731
dc.descriptionABSTRACT: Drug delivery represents one of the most important research fields within the pharmaceutical industry. Different strategies are reported every day in a dynamic search for carriers with the ability to transport drugs across the body, avoiding or decreasing toxic issues and improving therapeutic activity. One of the most interesting strategies currently under research is the development of drug delivery systems sensitive to different stimuli, due to the high potential attributed to the selective delivery of the payload. In this work, a stimuli-sensitive nanocarrier was built with a bifunctional acrylic polymer, linked by imine and disulfide bonds to thiolate chitosan, the latter being a biopolymer widely known in the field of tissue engineering and drug delivery by its biodegradability and biocompatibility. These polymer nanoparticles were exposed to different changes in pH and redox potential, which are environments commonly found inside cancer cells. The results proof the ability of the nanoparticles to keep the original structure when either changes in pH or redox potential were applied individually. However, when both stimuli were applied simultaneously, a disassembly of the nanoparticles was evident. These special characteristics make these nanoparticles suitable nanocarriers with potential for the selective delivery of anticancer drugs.
dc.descriptionCOL0065152
dc.format12
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherPharmaceutical Society of Japan
dc.publisherBIOPOLIMER
dc.publisherTokyo, Japón
dc.relationChem. Pharm. Bull.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/2.5/co/
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subjectAntineoplásicos
dc.subjectAntineoplastic Agents - Chemistry
dc.subjectQuitosano - Química
dc.subjectChitosan - Chemistry
dc.subjectDrug Carriers - chemical synthesis
dc.subjectPortadores de Fármacos - Química
dc.subjectDrug Carriers - Chemistry
dc.subjectConcentración de Iones de Hidrógeno
dc.subjectHydrogen-Ion Concentration
dc.subjectEspectroscopía de Resonancia Magnética
dc.subjectMagnetic Resonance Spectroscopy
dc.subjectNanopartículas - Química
dc.subjectNanoparticles - Chemistry
dc.subjectOxidación-Reducción
dc.subjectOxidation-Reduction
dc.subjectTamaño de la Partícula
dc.subjectParticle Size
dc.subjectPolímeros - Química
dc.subjectPolymers - Chemistry
dc.subjectCompuestos de Sulfhidrilo - Química
dc.subjectSulfhydryl Compounds - Chemistry
dc.titleChitosan-Acrylic Polymeric Nanoparticles with Dynamic Covalent Bonds. Synthesis and Stimuli Behavior
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typehttp://purl.org/coar/resource_type/c_2df8fbb1
dc.typehttps://purl.org/redcol/resource_type/ART
dc.typeArtículo de investigación


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