Assessment of processing and polymorphic form Effect on the powder and tableting properties of microcrystalline celluloses I and II

dc.creatorRojas Camargo, John
dc.creatorLópez López, Alvin de Jesús
dc.creatorGamboa, Yudi
dc.creatorGonzalez, Christian
dc.creatorMontoya, Fernando
dc.date2023-05-29T18:37:16Z
dc.date2023-05-29T18:37:16Z
dc.date2011
dc.date.accessioned2024-04-23T13:53:01Z
dc.date.available2024-04-23T13:53:01Z
dc.identifierRojas J, López A, Gamboa Y, González C, Montoya F. Assessment of processing and polymorphic form effect on the powder and tableting properties of microcrystalline celluloses I and II. Chem Pharm Bull (Tokyo). 2011;59(5):603-7. doi: 10.1248/cpb.59.603.
dc.identifier0009-2363
dc.identifierhttps://hdl.handle.net/10495/35145
dc.identifier10.1248/cpb.59.603
dc.identifier1347-5223
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9228658
dc.descriptionABSTRACT: Microcrystalline cellulose I (MCCI) is an excipient used as a diluent, disintegrant, glidant and binder for the production of pharmaceutical tablets. In this work, microcrystalline cellulose II (MCCII) was obtained from cotton fibers by basic treatment with 7.5 N NaOH followed by an acid hydrolysis. MCCI and MCCII materials were processed by wet granulation, dry granulation and spray drying. Either the polymorphic form or processing had no effects on the particle morphology or particle size. However, MCCII powders had a higher porosity, less packing tendency, degree of crystallinity, degree of polymerization and density, but a faster disintegration than MCCI. The tensile strength of MCCI was highly affected by the wet and dry granulation processes. Most of the resulting powder and tableting properties were dependent on the polymorphic form of cellulose, rather than on the processing employed.
dc.descriptionCOL0003623
dc.format5
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherPharmaceutical Society of Japan
dc.publisherDiseño y Formulación de Medicamentos Cosméticos y Afines
dc.publisherTokyo, Japón
dc.relationChem. Pharm. Bull.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/2.5/co/
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subjectCelulosa - Química
dc.subjectCellulose - Chemistry
dc.subjectCristalización
dc.subjectCrystallization
dc.subjectEstabilidad de Medicamentos
dc.subjectDrug Stability
dc.subjectExcipientes - Química
dc.subjectExcipients - Chemistry
dc.subjectCelulosa - Farmacología
dc.subjectCellulose - Pharmacology
dc.subjectExcipientes - Farmacología
dc.subjectExcipients - Pharmacology
dc.subjectHidrólisis
dc.subjectHydrolysis
dc.subjectTamaño de la Partícula
dc.subjectParticle Size
dc.subjectFotomicrografía
dc.subjectPhotomicrography
dc.subjectPolvos - Química
dc.subjectPowders - Chemistry
dc.subjectPolvos - Farmacología
dc.subjectPowders - Pharmacology
dc.subjectHidróxido de Sodio - Química
dc.subjectSodium Hydroxide - Chemistry
dc.subjectComprimidos - Química
dc.subjectTablets - Chemistry
dc.subjectComprimidos - Farmacología
dc.subjectTablets - Pharmacology
dc.subjectTecnología Farmacéutica - Métodos
dc.subjectTechnology, Pharmaceutical - Methods
dc.subjectResistencia a la Tracción
dc.subjectTensile Strength
dc.subjectDifracción de Rayos X
dc.subjectX-Ray Diffraction
dc.titleAssessment of processing and polymorphic form Effect on the powder and tableting properties of microcrystalline celluloses I and II
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typehttp://purl.org/coar/resource_type/c_2df8fbb1
dc.typehttps://purl.org/redcol/resource_type/ART
dc.typeArtículo de investigación


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