Artigo
Ex-Vivo and In-Vivo Studies in a Porcine Model for Experimental Validation of an Embedded System Designed for Radiofrequency Ablation of Hepatocellular Carcinoma
Registro en:
GAIDOS, O. F. et. al. Ex-Vivo and In-Vivo Studies in a Porcine Model for Experimental Validation of an Embedded System Designed for Radiofrequency Ablation of Hepatocellular Carcinoma. 4th World Congress on Electrical Engineering and Computer Systems and Sciences (EECSS’18), Madrid, Paper n. ICBES 122, Aug. 2018.
Autor
Gaidos, O. F.
Rosa, S. R. F.
Ishihara, J. Y.
Marques, M. P.
Institución
Resumen
The Hepatocellular Carcinoma is the main cause of morbidity and mortality in the world related to primary liver cancer. One of the principal treatment for hepatocellular cancer and effective clinical outcomes is Radiofrequency Ablation (RFA). In Brazil, the commercial equipments used in RFA are expensive and it isn’t open technology. One problem during the RFA procedure is the thermal lesion volume estimation because parameters such as temperature or impedance are not fully controlled in the ablation zone, generating an uncertainty in the surgical procedure. This paper presents prototype validation based on experimental ablation protocol applied in exvivo and in-vivo tests on porcine liver of an RFA embedded system for the treatment of primary liver cancer, based on experimental results, calculating area and volume in the ablation zone. Using the signals of temperature and bioimpedance on porcine liver and the data processing in a microcontroller, it controls the power of a custom radiofrequency generator designed up to 50 W and frequency of 400 kHz, this energy is applied across an umbrella-shaped RF electrode. The data are sent by RS232 protocol, showed on LCD screen and sent to a computer for later analysis. Finally, it was possible to validate a hardware prototype with low-cost and low-power applied to thermal ablation of liver tumors.