| dc.creator | Salvador, Marcos José | |
| dc.creator | Carvalho, João Ernesto de | |
| dc.creator | Wisniewski Junior, Alberto | |
| dc.creator | Kassuya, Cândida Aparecida Leite | |
| dc.creator | Santos, Élide Pereira dos | |
| dc.creator | Riva, Dilamara | |
| dc.creator | Stefanello, Maria Élida Alves | |
| dc.date | 2013-08-13T21:11:10Z | |
| dc.date | 2013-08-13T21:11:10Z | |
| dc.date | 2011-10 | |
| dc.date.accessioned | 2023-09-28T23:01:49Z | |
| dc.date.available | 2023-09-28T23:01:49Z | |
| dc.identifier | SALVADOR, M. J. et al. Chemical composition and cytotoxic activity of the essential oil from the leaves of Casearia lasiophylla. Revista Brasileira de Farmacognosia, Curitiba, v. 21, n. 5, p. 864-868, set./out. 2011. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000500013>. Acesso em: 13 ago. 2013. | |
| dc.identifier | 0102-695X | |
| dc.identifier | https://ri.ufs.br/handle/riufs/666 | |
| dc.identifier | Creative Commons Attribution License | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/9082860 | |
| dc.description | The essential oil obtained by hydrodistillation from fresh leaves of Casearia lasiophylla Eichler, Salicaceae, was analyzed by gas capillary (GC/FID and GC/MS). The cytotoxicity of the leaves essential oil was tested in vitro againstU251 (glioma), UACC-62 (melanoma), MCF-7 (breast), NC1-ADR/RES (ovarian-resistant), NCI-H460 (lung), PC03 (prostate), OVCAR-3 (ovarian), HT-29 (colon) and K562 (leukemia) human cancer cells and against VERO (no cancer cell). The yield of oil was 0.02%. Fifty two compounds were identified, representing 87.1% of the total of the oil. The main components were identified as germacrene D (18.6%), β-caryophyllene (14.7%), δ-cadinene (6.2%), and α-cadinol (5.4%). The oil exhibited antiproliferative activity against all cell lines (TGI<100 µg/mL), with exception of NCI-H460 cell line (TGI 191.31 µg/mL). The highest activity was observed against UACC-62 (TGI 7.30 µg/mL), and K562 (TGI 7.56 µg/mL) cell lines. The observed activity could be related to high content of germacrene D and β-caryophyllene, compounds known as cytotoxic. | |
| dc.format | application/pdf | |
| dc.language | pt_BR | |
| dc.publisher | Sociedade Brasileira de Farmacognosia | |
| dc.subject | Casearia lasiophylla Eichler | |
| dc.subject | Salicaceae | |
| dc.subject | Óleos essenciais | |
| dc.subject | Citotoxicidade | |
| dc.subject | Atividade anti-tumoral | |
| dc.subject | Germacreno D | |
| dc.title | Chemical composition and cytotoxic activity of the essential oil from the leaves of Casearia lasiophylla | |
| dc.type | Artigo | |
