Preparation, characterization, and pharmacological activity of Cymbopogon winterianus Jowitt ex Bor (Poaceae) leaf essential oil of B-cyclodextrin inclusion complexes

dc.creatorSantos, Priscila Laíse dos
dc.creatorAraujo, Adriano Antunes de Souza
dc.creatorQuintans, Jullyana de Souza Siqueira
dc.creatorBrito, Renan Guedes de
dc.creatorSerafini, Mairim Russo
dc.creatorMenezes, Paula dos Passos
dc.creatorSantos, Márcio Roberto Viana dos
dc.creatorAlves, Péricles Barreto
dc.creatorLucca Junior, Waldecy de
dc.creatorBlank, Arie Fitzgerald
dc.creatorLa Rocca, Viviana
dc.creatorAlmeida, Reinaldo Nobrega de
dc.creatorQuintans Júnior, Lucindo José
dc.date2018-02-05T18:33:17Z
dc.date2018-02-05T18:33:17Z
dc.date2015
dc.date.accessioned2023-09-28T22:40:01Z
dc.date.available2023-09-28T22:40:01Z
dc.identifierSANTOS, P. L. dos et al. Preparation, characterization, and pharmacological activity of Cymbopogon winterianus Jowitt ex Bor (Poaceae) leaf essential oil of B-cyclodextrin inclusion complexes. Evidence-Based Complementary and Alternative Medicine, v. 2015, 2015. Disponível em: <https://www.hindawi.com/journals/ecam/2015/502454/>. Acesso em: 05 fev. 2018.
dc.identifier1741-427X
dc.identifierhttp://ri.ufs.br/jspui/handle/riufs/7314
dc.identifierCreative Commons Atribuição-Sem Derivações-Sem Derivados 3.0 Não Adaptada (CC BY-NC-ND 3.0)
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9074879
dc.descriptionThis study aimed to evaluate the orofacial antinociceptive effect of the Cymbopogon winterianus essential oil (LEO) complexed in B-cyclodextrin (LEO-CD) and to assess the possible involvement of the central nervous system (CNS). The LEO was extracted, chromatographed, and complexed in B-cyclodextrin. The complex was characterized by differential scanning calorimetry (DSC) and thermogravimetry derivative (TG/DTG). Male Swiss mice (2-3 months) were treated with LEO-CD (50–200 mg/kg, p.o.), vehicle (distilled water, p.o.), or standard drug (i.p.) and subjected to the orofacial nociception formalin-, capsaicin-, and glutamateinduced. After the formalin test, the animals were perfused and the brains subjected to immunofluorescence for Fos. The rota-rod test (7 rpm/min) was carried out. Geraniol (37.57%) was the main compound of LEO. DSC and TG/DTG proved the complexation. The orofacial nociceptive behavior was significantly (p < 0.05) reduced. The number of Fos-positive cells was significantly changed in the dorsal raphe nucleus (p < 0.01), locus coeruleus (p < 0.001), trigeminal nucleus (p < 0.05), and trigeminal thalamic tract (p < 0.05). LEO-CD did not cause changes in motor coordination in the rota-rod test. Thus, our results suggested that LEO-CD has an orofacial antinociceptive profile, probably mediated by the activation of the CNS without changing the motor coordination.
dc.formatapplication/pdf
dc.languageeng
dc.publisherHindawi Publishing Corporation
dc.relationEvidence-Based Complementary and Alternative Medicine
dc.subjectCymbopogon winterianus
dc.subjectEssential oils
dc.subjectβ-cyclodextrin
dc.subjectÓleos essenciais
dc.subjectβ-ciclodextrina
dc.titlePreparation, characterization, and pharmacological activity of Cymbopogon winterianus Jowitt ex Bor (Poaceae) leaf essential oil of B-cyclodextrin inclusion complexes
dc.typeArtigo


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